N-Acetyl L-Tyrosine (NALT)

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NALT is also available in capsules.

Tyrosine is an amino acid found in many high protein foods like chicken, yogurt and peanuts. In humans, tyrosine helps the brain build neurotransmitters known as catecholamines, which include dopamine, norepinephrine and epinephrine. [1] Since these neurotransmitters play a vital role in many cognitive functions, tyrosine supplements have become popular among nootropic users. Such supplements are typically marketed as L tyrosine, which is the free form of the amino acid.

L Tyrosine Benefits and Effects

Research concerning L tyrosine’s effects on animals and people suggests several promising benefits including:

Improving Working Memory

Tyrosine supplements can help replenish neurotransmitters necessary for maintaining working memory. [2] Therefore, some students like to take L tyrosine for studying.

Assisting the Thyroid

By boosting availability of the neurotransmitter norepinephrine, tyrosine may help stimulate the release of thyroid hormones, which are responsible for repairing damaged cells. In studies of rats with thyroid deficiencies, subjects given tyrosine supplements performed better on cognitive tasks. [3] However, a link between L tyrosine and hyperthyroidism has been documented in patients who also take thyroid medications. Further research on L tyrosine and thyroid health is needed.

Boosting Dopamine Levels

Taking tyrosine may also increase dopamine production when needed; however, the effect is temporary since taking L tyrosine in high doses can slow neuronal firing, so L tyrosine and dopamine levels tend to level off. [4]

Improving Stress Resistance

Since stress deplenishes norepinephrine, taking tyrosine may increase your resistance to stress. Rats who were given tyrosine injections before being subjected to electric shock maintained consistent norepinephrine levels and demonstrated no resulting cognitive deficits. [5]

Managing Attention Deficit Disorders

Tyrosine has demonstrated promise for managing symptoms of attention deficit disorders, In one study testing the link between L tyrosine and ADHD, eight of 12 patients saw improvements following two weeks of tyrosine supplementation. However, those patients developed a tyrosine tolerance after six just weeks, so more research is needed on L tyrosine and ADD. [6]

Treating Depression

In several small scale studies, tyrosine has successfully decreased symptoms of depression better than a placebo. [7] A larger study yielded mixed results, but the researchers posited that tyrosine is likely most effective at treating depression stemming from dopamine and norepinephrine deficiencies. [8] Research on L tyrosine and anxiety is lacking, but since depression and anxiety are closely associated, it may be beneficial to take L tyrosine for anxiety as well.

Treatment of Parkinson’s Disease

Parkinson’s disease patients who were given tyrosine and probenecid together experienced a spike in homovanillic acid in their cerebrospinal fluid, which indicates improved dopamine production. Since Parkinson’s affects dopamine-producing neurons, tyrosine could help prevent progression of the condition. [9]

Increased Inhibition

Taking tyrosine may help with impulse control. In a study of humans, subjects given tyrosine injections performed better on a stop-signal task than a control group. [10]

Acclimating to Cold Climates

Taking tyrosine may help individuals cope with the physical and psychological stress that comes with adapting to cold temperatures and elevated altitudes. In a long-term study of scientists living in Antarctica, subjects who took daily tyrosine supplements during the winter months demonstrated significant improvements in mood. The supplements didn’t have the same effect during warmer months. [11]

How L Tyrosine Works

L Tyrosine: What Is It?

The human body naturally produces tyrosine as a precursor to dopamine, norepinephrine and epinephrine. Thus, taking L tyrosine nootropic supplements can help the brain replenish these neurotransmitters as they get used up. [1]

Does L Tyrosine Give You Energy?

Many users claim to take L tyrosine for energy, but the relationship between L tyrosine energy is often misunderstood. It is important to note that taking tyrosine does not increase the overall quantity of neurotransmitters in your brain at one time. Rather than directly stimulating production of dopamine or norepinephrine, tyrosine gets stored for use when existing supplies are depleted.

Therefore, it’s believed that tyrosine only improves physical or cognitive performance in circumstances where catecholamine levels are being depleted. In other words, tyrosine supplements don’t give you more energy; instead, they ensure that you have a backup supply ready once you’ve used up your current energy stores. [12] Consequently, some athletes take L tyrosine for bodybuilding because it increases their endurance during workouts, which allows them to push their performance limits.

L Tyrosine Dosage

L Tyrosine: When to Take

Standard dosing has yet to be established, but online L tyrosine reviews suggest taking 500-2000mg prior to an acute stressor. For best results, tyrosine should be taken 30-60 minutes before exercising or performing a mentally demanding tasks. It can be taken 2-3 times per day. Some people use L tyrosine as a caffeine replacement, so they take it in the morning in place of a cup of coffee. L tyrosine’s half life is relatively long. so some people are satisfied with just one dose when they wake up.

L Tyrosine vs Tyrosine in Other Forms

L tyrosine tablets are the most popular type of tyrosine supplement. The “L” simply indicates that tyrosine isn’t connected to any other amino acids. In addition to L tyrosine, there is another tyrosine supplement called N-Acetyl-L-Tyrosine, or NALT. NALT is basically L tyrosine with an acetyl group attached to improve bioavailability. Both supplements work the same and have the same benefits, but NALT is more potent, so it should be taken in smaller doses. Of course, you can also find L tyrosine in foods like dairy, nuts and poultry. Other L tyrosine food sources include certain beans and whole grains.

No L tyrosine overdoses have been reported, but more than 12 grams of L Tyrosine per day may be toxic. To avoid digestive issues, try splitting doses in two separated by 30 minute intervals.

L Tyrosine Side Effects

Fortunately, L tyrosine’s health benefits come with very few potential side effects. Taking L tyrosine long term appears to be safe for adults, but it’s not recommended to take L tyrosine during pregnancy. You should also avoid mixing L tyrosine and alcohol. Due to a potential link between l tyrosine and high blood pressure, patients with hypertension should be careful when taking such supplements.

Does L Tyrosine Make You Tired?

Although many people find tyrosine supplements to be beneficial, some users actually feel more tired after taking L tyrosine. However, L tyrosine and insomnia are also commonly linked, so be cautious of taking L tyrosine before bed. More research is needed regarding the effects of L tyrosine on sleep habits.

Does L tyrosine Make You Gain Weight?

Unwanted weight gain as well as stiffness in the shoulders and neck have also been reported. [13] Painful headaches, sometimes called “L tyrosine migraines,” have also been reported.

L Tyrosine Drug Interactions

While L tyrosine has shown promise for treating Parkinson’s disease, it can interfere with some Parkinson’s treatments. [14] Likewise, although some people take L tyrosine for thyroid hormone production, combining tyrosine supplements with thyroid hormone pills can actually lead to hyperthyroidism. [15] Ask your doctor about L tyrosine’s interactions with other medications you’re currently taking.

L Tyrosine Stacks

Taking tyrosine along with the tryptophan supplement 5-HTP can help combat depression since 5-HTP boosts serotonin, another neurotransmitter that affects mood. [13] L Tyrosine and Super Cortisol is purportedly a good combination for fighting fatigue.

L Tyrosine also pairs well with caffeine, L theanine, choline, sulbutiamine, aniracetam and noopept. In fact, all of the above can be combined into a comprehensive twice-daily stack. However, sulbutiamine and aniracetam should only be taken in the morning, and noopept should only be taken during the afternoon. Since L tyrosine and vyvanse are both used to treat ADHD, combining the two may be beneficial. L tyrosine and magnesium are also a popular combination.

L Tyrosine vs Adderall

L Tyrosine and adderall are sometimes compared since adderall also stimulates dopamine production. Taking these drugs together seems to have little benefit, but L tyrosine is said to help with adderall withdrawal. Other people have used L tyrosine for withdrawal from other substances. For example, some users take L tyrosine for opiate withdrawal.


1. https://www.ncbi.nlm.nih.gov/pubmed/10837313
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863934/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308793/
4. http://www.sciencedirect.com/science/article/pii/036192308890161X
5. https://www.ncbi.nlm.nih.gov/pubmed/6727560
6. https://www.ncbi.nlm.nih.gov/pubmed/3300376
7. http://journals.sagepub.com/doi/abs/10.1177/026010618400300305
8. https://www.ncbi.nlm.nih.gov/pubmed/2142699
9. https://www.ncbi.nlm.nih.gov/pubmed/6175872
10. https://www.ncbi.nlm.nih.gov/pubmed/24433977
11. https://www.ncbi.nlm.nih.gov/pubmed/18274206
12. https://www.ncbi.nlm.nih.gov/pubmed/26424423
13. https://www.iherb.com/r/Now-Foods-L-Tyrosine-500-mg-120-Capsules/836/?p=1&fr=5&rcode=coh780
14. https://www.ncbi.nlm.nih.gov/pubmed/7219901
15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308793/


Curated Reviews

“It is definitely strong. No reason to take more than 350mg once per day. Perhaps another 250-300mg prior to exercise for a second dose in one day. I only take it on an empty stomach like normal tyrosine,inthe morning, before consuming coffee. Caffeine will certainly accentuate the noradrenic and dopaminergic effects, be careful not to get overstimulating or overstack! No need whatsoever to combine with any other stimulants IMHO, no mod or oxiracetam necessary, in my exp. it will just lead to severage excitory burnout and headaches. I like it more than regular L Tyrosine for sure. Slow shipping to TX, wish I still lived in MA! Good product, good package. STRAIGHT FORWARD NOOTS BRAHHH”– Erich S

“Great for boosting my mood and for providing an overall, general good feeling. Nothing high and spectacular, but it does have a consistent and welcomed effect. I take it every day, about 350 mg per day, sometimes 2 times per day. I can feel the difference when I don’t take it. I have taken the standard L-Tyrosine, but this N-Acetyl L-Tyrosine version seems to work a little faster and better than the standard form. It’s rather soluble, so it can be mixed with just about anything.”– Michael I

“I have some guys I work with who were curious what all these weird bags I take to work were, and one of them was NALT ordered through, of course, Powder City. My friend has been weight lifting for some time now and ever since he tried NALT he always asks for more. I took this while Laying Concrete, while Landscaping, and some minor Construction and I felt great after work! I love it! MIX WITH ANYTHING THAT BRINGS YOU UP AND YOU WON’T GO DOWN AS HARD :)”– Justin C

“Fast shipping and a great value! I add this to my own pre workout and it helps negate the negative side effects from the stimulants in the mix, as well as enhance mood. I mix it with a flavored water enhancer and haven’t noticed any strong taste. Also mixes pretty easy. My pre workout: 2g Beta Alanine 1g Taurine 6g Creatine Mono 350mg NALT 200mg L-Theanine 10mg Noopept 120mg Caffeine” – Mandyk

“This stuff chills me out, and I haven’t had a restless night since I started taking it before bed. It has a definite sedative effect so I don’t take it in the morning. Overall I get a better night’s sleep, and am in a better mood the next day. One of the best things about this amino, for me, is that it tastes good. A little bitter at first but after you wash it down with water it’s tangy and pleasant. I wouldn’t call it delicious, but it’s a nice change of pace from most of the nootropics I’ve tried.”– Ian M.

“I wasn’t planning to buy this because of the complex description. After a discussion with the owner about what I was looking for he recommended NALT. Good choice! It has a mind calming effect with a mild mood uplift. Best of all there is a smoothness to it, no disruptive side effects. A couple of the substances I take are stimulants and they can be rough. NALT is a good way to smooth out the kinks. 200mg a day seems to be enough for me but no problem taking more if needed.”– Robert A.

Additional information

Weight0.113 g

100 Grams, 1 Kilogram


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