Artichoke Extract and Forskolin

5.8

Focus

8.0 /10

Motivation

5.0 /10

Memory

4.5 /10

Artichoke Extract and Forskolin

Boost Energy
Cognitive
Improve Focus
Improve Memory
Longevity
Mental Health
Nootropics
Mood Support

Description

Summary

Forskolin, is found in the roots and stems of Coleus forskohlii [1]. Forskolin can treat heart diseases, glaucoma, asthma and some cancers [1]. Other reports have suggested forskolin can treat cardiovascular disorders and even lower blood pressure [3].

Mechanisms of action 

Forskolin increases cyclic adenosine monophosphate (cAMP) concentrations [3; 4]. cAMP is an extremely important signal necessary for the proper response of cells to certain molecules [5].

cAMP is suggested to be involved in the regulation of memory; with forskolin considered as a good candidate for Alzheimer’s Disease [6].

Forskolin-cAMP production is linked to PDE4. PDE4 inhibitors increase the levels of cAMP, exhibiting anti-inflammatory effects [6]. Selective inhibitors of PDE4 have been reported as important in controlling depression and cognitive function [7]. The expression of PDEs play a role in regulating cAMP-mediated signalling [8].

Benefits and Effects

Along with its ability to treat cardiovascular disorders and blood pressure [3], forskolin can also treat hypertension and asthma [8]. Forskolin can treat mood disorders, promote lean body mass, along with possessing anti-cancer properties [9].

Forskolin and hair loss

Forskolin induces the production of cAMP [3], and this can activate hair follicle activity [10].

Forskolin and asthma

In a single-blind clinical study, a 10mg capsule forskolin dose, delivered orally over 6 months showed effectiveness in preventing asthma attacks [11].

Forskolin and weight loss

The ability of forskolin to increase intracellular levels of cAMP leads to the stimulation of lipolysis, which promotes the breakdown of stored fats [12]. Obese individuals have lower cAMP production, so, theoretically, forskolin may trigger weight loss [13].

A 250mg dose of forskolin extract was shown to induce weight loss – fat percentage and mass – over a 12-week period in obese males [12].

Forskolin in depressed patients

Forskolin, administered intravenously at a dose between 0.5 – 2 mg/kg, demonstrated that forskolin had a positive impact in depressed patients [14].

Forskolin extract 

Forskolin is generally extracted using a range of organic solvents [13]. An extract was used to study the skin diffusion properties of forskolin [15]. Forskolin extract could be effectively delivered through the outermost layer of the skin [15].

Forskolin and testosterone

A 250mg forskolin extract raised serum free testosterone levels [16]. A low dose of forskolin was shown to induce higher hormone production [17]. The importance of having steroid-producing machinery within a cell is crucial for the synthesis of testosterone [18].

Dosage 

Forskolin is well-tolerated at doses of 50-100mg/kg body weight [3]. Other academic sources report that oral administration of 50mg/day does not produce significant side effects in individuals [19].

Side effects and safety

Side effects with forskolin have yet to be fully evaluated [19]. Forskolin’s safety has also been assessed in a 3-month topical, cream, treatment in animals [20]. Researchers of this study found that forskolin topically administered to animal skin in a low dose caused no toxic reactions [30]. Although forskolin might be considered safe, there is potential for herb-drug interactions in patients who might be on combination therapy [21].

 

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Sources

Sources

  1.  Gracy L. SAILO and Davis J. BAGYARAJ, 2005. Influence of different AM-fungi on the growth, nutrition and forskolin content of Coleus forskohlii. The British Mycological Society, 7: 795-798.
  2. Khalid Pasha Mohammed, Archana Aarey, Shayesta Tamkeen, Parveen Jahan, 2015. Forskolin: Genotoxicity assessment in Allium cepa. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 777: 29-32.
  3. Irini Pateraki, Johan Andersen-Ranberg, Britta Hamberger, Allison Maree Heskes, Helle Juel Martens, Philipp Zerbe, Søren Spanner Bach, Birger Lindberg Møller, Jörg Bohlmann, and Björn Hamberger, 2014.
  4. Srinivasa Rao Vattikonda, Nageswara Rao Amanchi and Sabita Raja S. 2014. Antifeedant activity of forskolin, an extract of Coleus forskohlii, against Papilio demoleus L. (Lepidoptera: Papilionidae) larvae. Pelaiga Research Library, 4:1, 237-241.
  5. Brice Ayissi Owona, PhD, Caroline Zug, MSc, Hermann J. Schluesener, PhD, MD, and Zhi-Yuan Zhang, PhD, 2016. Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis. Journal of Neuropathology and Experimental Neurology, 75:7.
  6. Lirlaˆndia P. Sousa, Fernando Lopes, Douglas M. Silva, Luciana P. Tavares, Ang ́elica T. Vieira, Ba ́rbara M. Rezende, Aline F. Carmo, Remo C. Russo, Cristiana C. Garcia, Cla ́udio A. Bonjardim, Ana L. Alessandri, Adriano G. Rossi, Vanessa Pinho, and Mauro M. Teixeira, 2010. PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF- B-independent manner. Journal of Leukocyte Biology, 87.
  7. Simon J. MacKenzie, George S. Baillie, Ian McPhee, Carolynn MacKenzie, Rachael Seamons, Theresa McSorley, Jenni Millen, Matthew B. Beard, Gino van Heeke & Miles D. Houslay, 2002. Long PDE4 cAMP speci®c phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
  8. Teresa Röhrig, Olga Pacjuk, Silvia Hernández-Huguet, Johanna Körner, Katharina Scherer and Elke Richling, 2017. Inhibition of Cyclic Adenosine Monophosphate- Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents. Medicines, 4: 80.
  9. Shirish M. Harde, Rekha S. Singhal, 2012. Extraction of forskolin from Coleus forskohlii roots using three phase partitioning. Separation and Purification Technology, 96: 20-25.
  10. Alexandra Amaro-Ortiz, Betty Yan and John A. D’Orazio, 2014. Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation. Molecules, 19.
  11. R GONZÁLEZ-SÁNCHEZ1, X TRUJILLO2, B TRUJILLO-HERNÁNDEZ3, C VÁSQUEZ2, M HUERTA2 AND A ELIZALDE, 2006. Forskolin versus Sodium Cromoglycate for Prevention of Asthma Attacks: a Single-blinded Clinical Trial. The Journal of International Medical Research, 34: 200-207.
  12. N. Virgona, Y. Taki, K. Umegaki, 2009. A rapid HPLC with evaporative light scattering method for quantification of forskolin in multi-herbal weight-loss solid oral dosage forms. Pharmazie, 65: 322-326.
  13. CARMEN CIOTONEA and CORINA CERNĂTESCU, 2010. BIOLOGICAL ACTIVE EFFECTS OF FORSKOLIN EXTRACT.
  14. Y. Bersudsky, M. Kotler, M. Shifrin and R.H. Belmaker, 1996. A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. Journal of Neural Transmission, 103: 1463-1467.
  15. Jing Chen, Dana C. Hammell, Malinda Spry, John A. D’Orazio, and Audra L. Stinchcomb, 2009. In Vitro Skin Diffusion Study of Pure Forskolin versus a Forskolin-Containing Plectranthus barbatus Root Extract. Journal of Natural Products, 72:4, 769-771.
  16. Michael P. Godard, Brad A. Johnson, and Scott R. Richmond, 2005. Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men. Obesity Research, 13:8.
  17. Kristine von Krogh, Hannah Harjen, Camilla Alma , Karin E. Zimmer, Ellen Dahl, yIngrid Olsaker, zErik Taubøll, Erik Ropstad, and Steven Verhaegen, 2010. The effect of valproate and levetiracetam on steroidogenesis in forskolin-stimulated H295R cells. Epilepsia, 51:11, 2280-2288.
  18. V. Papadopoulos, 2010. How is the synthesis of testosterone regulated? American Society of Andrology.
  19. Virginie Follin-Arbelet, Kristine Misund, Elin Hallan Naderi, Hege Ugland, Anders Sundan & Heidi Kiil Blomhoff, 2015. The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Scientific Reports, 5:13001.
  20. Malinda L Spry, Jillian C Vanove, Timothy Scott, Osama Abona-Ama, Kazumasa Wakamatsu, Shosuke Ito and John A. D’Orazio, 2008. Prolonged treatment of fair-skinned mice with topical forskolin causes persistent tanning and UV protection. Pigment Cell Melanoma Research, 22: 219-229.
  21. Xunshan Ding and Jeff L. Staudinger, 2005. Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway. The Journal of Pharmacology and Experimental Therapeutics, 312: 849-856.

 

Also known as:Artichoke, Cynarin
Type:Racetam
Good for: , , , , , , ,
Stacks well with: Nootropics Sampler
Typical dose:50 - 900 mg
Half Life :Coming soon...
Artichoke Extract and Forskolin

Artichoke Extract and Forskolin

Boost Energy
Cognitive
Improve Focus
Improve Memory
Longevity
Mental Health
Nootropics
Mood Support