Description
Summary
Table of Contents
Lion’s mane mushroom has been widely used in traditional medicines within Asia.
Benefits and Effects
Lion’s Mane mushroom health benefits include, inducing Nerve Growth Factor synthesis as well as promoting neurite outgrowth [1]
Alleviate neurodegenerative disease symptoms
Lion’s Mane was able to regenerate damaged nerves in rats which resulted in the return of hind limb function. [2]
Orally administered Lion’s Mane was found to provide a protective effect against the progression of Parkinson’s disease in Mice. [3]
Lion’s mane and Alzheimer’s
Animal studies shown lions mane is able to reduce the amount of amyloid plaque which plays a crucial role in Alzheimer’s disease [4]
Improvement of cognitive function
A double-blind, placebo-controlled study on middle-aged to elderly people suffering from mild cognitive impairment found that cognitive function improved significantly in patients being administered the Lion’s Mane Mushroom. [5]
A study on mice found dietary supplementation of Lion’s Mane Mushroom caused significant improvement in recognition as well as helping preserve short term memory. [6]
Improving depression
In a four-week placebo-controlled study, those consuming Lion’s Mane Mushroom experienced significantly lower levels of depression and anxiety. [7]
Anti-Inflammatory Properties
Lion’s Mane Mushroom shows anti-inflammatory effects, as well as the ability to prevent inflammation of adipose tissue associated with obesity. [8]
Lion’s Mane can promote gut health. One study found it to have direct inhibitory effects against bacterial stomach infection H. pylori. [9]
Accelerated wound healing
A study on rats using topical mushroom extract from lion’s mane found not only was wound healing faster but it also produced less significant scarring. [10]
How Lion’s Mane Mushroom Works
Lion’s Mane is abundant in bioactive compounds. [4]
Lion’s Mane Mushroom polysaccharides, benefits include; antitumor, immunomodulation, anti-gastric ulcer, neuroregeneration, neuroprotection, anti-oxidation, anti-fatigue and more. [11]
Dosage
Recommended dosage is 500-1000mg taken between one and three times a day. We recommend you start with lower doses and increase if necessary.
Lion’s Mane could be safely administered at daily doses of up to 1000mg/kg body weight for ninety days with no adverse effects. [12] Dosages up to three times with no adverse effects. [13] Lion’s Mane administered at a dose of 5000mg/kg during an acute toxicity study and found no toxicological signs. [14]
Side effects
Lion’s Mane Mushroom is non-toxic and considered a safe nootropic, there are multiple studies which recorded no adverse effects even with high dosages. [14] [5]
A 63-year-old man suffered acute respiratory distress associated with Lion’s Mane Mushroom. [15] One 53-year-old man had an allergic reaction. The patient had a patch test which was positive and sensitization was confirmed with further testing. [16]
Stacks
Lion’s Mane Mushroom can be combined with Pyrroloquinoline quinone (PQQ) for optimizing nerve growth factor. [17]
Lion’s Mane Mushroom can also be combined with Phosphatidylserine (PS) to promote brain health. PS supports cognitive functions and can safely slow, halt, or reverse biochemical alterations and structural deterioration in nerve cells. [18]
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