Table of Contents
Uridine has gained attention for its therapeutic potential in various diseases of the circulatory, respiratory, and nervous systems . After crossing the blood-brain barrier, uridine acts as a neuroprotectant, as well as a building block of brain phosphatides and synapse formation .
Benefits and Effects
Elevated Cognition and Memory
It is believed that uridine is able to carry out memory-enhancing functions primarily by enhancing neurite outgrowth and activating synaptic protein synthesis .
Improved Synaptic Function
A 2009 study showed that uridine and DHA increased both neurites and dendritic spine levels, thus increasing synapse formation and inhibiting cognitive decline .
One study showed the anxiolytic action of uridine in a laboratory mouse model. Results indicated that anxiety states were ameliorated via uridine’s central serotonin-negative mechanism of action .
One study evaluated the effects of uridine supplementation on adolescents with depressive symptoms, and found that uridine was associated with a decrease in symptoms on the Children’s Depression Rating Scale. .
A 2013 study observed a decrease in stress-induced aggressive behaviour in previously isolated laboratory mice as a result of oral uridine supplementation .
A Russian study evaluated the impact of uridine and its derivative nucleotides on coronary flow and heart rate in a laboratory rat model. Results indicated that, though there was no impact on heart rate, uridine yielded a protective effect in terms of coronary flow and dilation .
Moreover, research indicates that uridine adenosine tetraphosphate may contribute to cardiovascular homeostasis by acting on endothelial and smooth muscle cells .
Treatment of Bronchial Asthma
Uridine has demonstrated anti-inflammatory and anti-fibrotic mechanisms in laboratory animal models of lung injury and/or bronchial asthma. One study found that oral uridine supplementation reduced leukocytes and inflammatory cytokines in male mice exhibiting acute lung injury .
How it works
Uridine monophosphate refers to uridine in its monomer form . Uridine monophosphate’s primary mechanism of action lies in its signaling ability to induce the brain to produce CDP-choline, signaling the neurotransmitters phosphatidylcholine and acetylcholine. .
Uridine monophosphate also plays a pivotal role in the metabolism of galactose, a monosaccharide sugar essential for the glycolysis pathway. .
The standard uridine dosage for cognitive benefit is 150-250 mg twice daily .
Uridine supplementation could be carcinogenic. Uridine homeostasis was pharmacologically disrupted in laboratory mice, uracil caused DNA damage that in turn induced spontaneous tumorigenesis. .
Side effects such as headaches, nausea, diarrhea, and/or vomiting have been reported in uridine monophosphate supplementation .
Uridine and Choline or CDP-Choline
Consuming choline in eggs, meat, poultry, dairy, wheat, or fish, or via supplement, supports uridine’s mechanism of action and may inhibit side effects such as headaches or abdominal pain .
Uridine and Docosahexaenoic Acid (DHA)
In conjunction these have been shown to accelerate synaptic formation and increase brain phospholipids in vivo. 
Uridine and Alpha-GPC
Alpha-GPC is a cholinergic cognitive enhancer that has gained some attention in clinical research as a potential therapeutic agent against Alzheimer’s dementia .