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Etizolam is a thienodiazepine compound which is related to the benzodiazepine drug class. 
Etizolam is not authorized by the FDA for medical use in the United States. However, it is an unscheduled drug and is legal to use for research purposes. 
Etizolam Benefits and Effects
Etizolam was originally developed as a treatment for anxiety and sleep disorders but has been found to be effective in other treatments too. 
Etizolam were found to show a marked improvement in chronic anxiety and phobic ideas.  Another study, patients – treated over 5 weeks – showed significant improvement in anxiety and depressive symptoms. 
Etizolam was compared with Alprazolam and Bromazepam in the treatment of generalized anxiety disorder. Etizolam outperformed both of the other drugs in the trial for its antidepressant effect. 
May reduce auditory hallucinations in schizophrenia patients
One study using Etizolam showed a complete disappearance of auditory hallucinations in a schizophrenic patient. 
May combat insomnia
A study using rats showed that a regular dosage of Etizolam significantly reduced the sleep latency of the subjects. Insomnia returned as Etizolam dosage stopped. 
May reduce pain
Etizolam was used to test pain reduction from tension-type headaches, using a combination of Etizolam and NSAID. Young and female patients showed a statistically significant reduction in pain using the combination of Etizolam and NSAID. 
How Etizolam works
Etizolam is absorbed via the gastro-intestinal tract. Peak plasma concentrations occur between 0.5 – 2 hours in human trials, with half-life at about 3.4 hours , with bioavailability between 90 to 95%  Excretion is via urine (30% in rats and 40% in mice) and faeces (70% in rats and 60% in mice) 
Etizolam interacts on the benzodiazepine site of the GABA-A receptor; binding to its regulatory site and causing the opening of GABA induced Chloride channels, facilitating GABA transmission through the channel. 
Studies show that treatment using Etizolam may reduce the need for surgery in the case of chronic subdural hematoma. 
Etizolam dosing tend to be in the range 0.25g to 3.0 g tablets; taken one, to three times daily.
One overdosed patient was admitted to an emergency room after consuming a large quantity of Etizolam tablets along with other unknown substances. .
Etizolam is not recommend for use by pregnant or breast-feeding women; it can pass through the placenta. In addition, benzodiazepines like Etizolam are excreted in breast milk. They can have a sedatory effect on the neonate. 
Pyrexia or raised temperatures is the most common side effect. 
Patients taking Etizolam were found to have a significant prolongation of P300 latency.  Day-time drowsiness is also documented. 
One case of Etizolam dependency has been reported.  However, the patient dropped out of a follow up program. In another case, a female patient was successfully weaned from Etizolam through a planned reduction in dosage and replacement drug.