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Yohimbine hydrochloride (HCl) is a prescription stimulant that is most commonly known to help fight against erectile dysfunction.  More recently, bodybuilders have been seen using yohimbine for fat loss.  
Benefits and Effects
Treating Erectile Dysfunction
Short-term treatment with an oral combination of yohimbine and L-arginine improved mild to moderate symptoms of erectile dysfunction in a cohort of married adult males.  In another human study, a third of the male subjects experienced either partial or full restoration of sustained erections after two to three weeks of oral yohimbine treatment. 
In two separate rat studies, yohimbine supplementation increased sexual arousal, sexual motivation, and frequency of ejaculation.  
Female rat and human studies did not observe any significant effect on sexual behaviour following yohimbine treatment.   Yohimbine did not increase or decrease sexual desire in female human participants. 
Accelerating Weight Loss
Oral yohimbine administration in healthy adult males resulted in the most significant increase in lipid mobilization when compared with other alpha-adrenoreceptor antagonists. 
Intensifying Cardiovascular Benefit
In conjunction with a hypocaloric diet, the addition of yohimbine increased cardiac load during dynamic exercise in obese women.  This means that the cardiovascular benefits of aerobic physical activity are enhanced as a consequence of yohimbine intake.
Elevating Energy Levels
In the case of yohimbine, its effects stimulate the sympathetic nervous system—also known as the fight or flight response.  
Trained endurance athletes may opt to take yohimbine pre-workout to elevate their energy levels and heighten their physiological responses to physical exertion. 
Reducing Fear and Social Anxiety
Preliminary animal research findings report that yohimbine treatment successfully facilitated fear extinction in conditionally feared mice. 
A prescription for yohimbine could help treat the symptoms of people living with type 2 diabetes. The onset of type 2 diabetes has been associated with an alpha-adrenergic receptor.  
Decreasing Risk of Blood Clots
Dietary supplementation with yohimbine may also inhibit epinephrine-induced blood clotting.  Yohimbine promotes the conversion of epinephrine to norepinephrine, thus reducing the risk of blood clots. 
How Yohimbine Works
Yohimbine is a naturally occurring indole alkaloid found within the bark of the yohimbe tree.   Indole alkaloids execute metabolic functions that affect both the central and peripheral nervous systems; yohimbine acts primarily on the peripheral system. 
According to pharmacological analysis, half-life of yohimbine is rapid, between half a minute to eighteen minutes after consumption.  The effects of yohimbine are likely to last anywhere from a quarter of an hour to two and a half hours, at most. 
Recommendation yohimbine-HCl dosage is 0.2mg/kg of bodyweight.
The maximum yohimbine dosage for erectile dysfunction is 42mg. 
An appropriate yohimbine dosage for fat loss is 20mg/day, divided into two equal portions.  It is recommended that you take your doses before a meal to offset any fluctuations in insulin levels, as a result of the yohimbine.
Most common yohimbine hydrochloride side effects include anxiety, headache, dizziness, elevated blood pressure, and rapid heartbeat. 
At higher doses, yohimbine can even cause psychotropic effects, like hallucinations. Individuals who suffer from any kind of heart condition and/or high or low blood pressure should not take yohimbine.
The potential for drastic changes in heart rate and/or blood pressure could put your health in severe danger.  Never combine yohimbine with an anti-depression medication unless you have been told otherwise by a healthcare professional.
A popular stack combination is L-arginine glutamate and yohimbine hydrochloride.   The combined oral administration of these stacked supplements has been shown to be a safe and effective short-term solution to erectile dysfunction.