Known Chemical Data
Table of Contents
|Systematic (IUPAC) name||(RS)-ethyl 2-phenyl-2-piperidin-2-ylacetate|
|Molar mass||247.33274 g/mol|
|Online Synonyms||Ethyphenidate;thylphenidate;ethylphenidate;Ethylphenidate [57413-43-1];phenyl-piperidyl-acetic acid ethyl ester;ethyl 2-phenyl-2-piperidin-2-ylacetate HCl;2-Piperidineaceticacid, a-phenyl-, ethyl ester;alpha-Phenyl-2-piperidineacetic acid ethyl ester;Ethylphenidate 2-Piperidineaceticacid, a-phenyl-, ethyl ester|
Ethylphenidate 57413-43-1 CHEMBL534479 Ethyphenidate Ethyl phenidate Phenyl-piperidin-2-yl-acetic acid ethyl ester; hydrochloride AC1MIVU6 SCHEMBL727938 CHEMBL1187932 BDBM50165211 AKOS025149438 EBD2197478 ethyl 2-phenyl-2-piperidin-2-ylacetate AK313103 HE052768 HE354966 Ethyl 2-phenyl-2-(piperidin-2-yl)acetate X5896 2-Piperidineaceticacid, a-phenyl-, ethyl ester 2-Piperidineacetic acid, alpha-phenyl-, ethyl ester S14-2940 (2R,2”R)-Phenyl-piperidin-2-yl-acetic acid ethyl ester; hydrochloride (2S,2”S)-Phenyl-piperidin-2-yl-acetic acid ethyl ester; hydrochloride
ETHYLPHENIDATE – Discovery, History & Research
Ethylphenidate was first described in the literature as long ago as 1998 discussion of Tamoxetine in the treatment of ADHD. Some of the most relevant research was in 2005 with the “synthesis and pharmacology of ethylphenidate enantiomers”.
Ethylphenidate seems to have first been discussed by research and development teams within Elli lilly drug company as early as 1998. Since then, Ethylphenidate seems to have been one of the oldest known research chemicals to explode on the scene with the global online research chemical movement in 2009. Alongside, Mephedrone and Methiopropamine, Ethylphenidate was distributed online and has had extensive research conducted informally and anecdotally on its subjective effects.
Since Ethylphenidate is essentially a product of Ritalin (methylphenidate) taken in combination with Alcohol (ethanol) – so much of its effects can be characterised as a metabolite of this Co-administration.
Although not internationally controlled, Ethylphenidate has found its way into the list for banned substances after its detection in toxicology reports and other major test purchases.
As of around 2015, Ethylphenidate became illegal for purchase without a valid government licence in most western countries, including the manufacturing origin country – China.
Since 1998 there have been several research papers published on the co-abuse potential of Ritalin with Alcohol, as this causes Ethylphenidate to be produced in vivo. Considering that Ritalin is a globally recognised treatment for ADHD, the scientific community has found vast funding for this harm prevention research.
Below you may find a list of the research which has been conducted over the last 20 years on Ethylphenidate. These are the PubMed identifier numbers for the studies.
ETHYLPHENIDATE – Chemical Structural Data
Ethylphenidate is a synthetic compound consisting of a phenethylamine core with an ethyl group attached. Structurally similar to amphetamine, Ethylphenidate features a substitution at the Rα – incorporated within the piperidine ring. Structurally speaking, Ethylphenidate differs from Methylphenidate (Ritalin) in that it has an elongated carbon chain. Ethylphenidate is thought to be produced as a chiral racemic mixture.
ETHYLPHENIDATE – Structure-Activity & Chemical Similarity Predictions
Based on the known in vivo action of Ritalin, and the fact that Ethylphenidate is a product of alcohol and Ritalin after co-ingestion and liver metabolism. The following receptor binding data has been described in rodent studies.
|Compound||Binding DAT||Binding NET||Uptake DA||Uptake NE|
Ethylphenidate acts as a potent stimulant with primary affinity for the dopamine and norepinephrine receptors.
Key Areas of Research
Samples of ETHYLPHENIDATE to purchase online may be used in the following scientific applications.
- As a forensic sample and/or for forensic chemical catalogues.
- Cocaine addiction and liver metabolism of alcohol with stimulant drugs
- Norepinephrine and dopamine receptor binding studies.
- Primary ADHD research.
- As a reference sample for Toxicology laboratories.
- As a chemical reagent and/or intermediate
- Pharmaceutical Intermediate
- As a research chemical sample within studying pharmacology of receptor binding assays.
- Affinity and Efficacy Receptor profiling.
- Reference sample for the application within future therapeutic compounds
- Pure reference standard for chemical analytical libraries using HPLC, FTIR, NMR and GC/MS equipment
ETHYLPHENIDATE – Online Anecdotal Reports
Ethylphenidate has been synthesised and produced, in bulk, from Chinese laboratories for a number of years now. Online, there has been in-depth Ethylphenidate reviews and reports, describing the subjective experiences of users who’ve bought Ethylphenidate in the USA, UK and other major research chemical hubs.
Forum links to anecdotal discussion by those who are able to buy Ethylphenidate crystals online.
Chemical Safety, Legality & Indented Use
This is a research chemical compound. Sold as an analytical standard, reagent or laboratory tool for in vitro (outside a living organism) research only. This compound is not for human consumption or any form or in vivo research.
It is the sole responsibility of the purchaser to ensure this compound is legal to purchase and import for research chemical purposes in their country.
This compound is intended to be used in strict laboratory conditions, following all proper precautionary protocol for any novel and untested chemical. The toxicological and physiological action of this compound have not been assessed and so extreme caution should be observed when handling this compound. Please follow proper health and safety guidelines, in a well ventilated and well equipped laboratory when handling this compound.