Tribulus Terrestris


Digestive Health


Heart Health




Tribulus Terrestris

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Digestive Health
Heart Health
Immune Support
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Tribulus terrestris is used as a main constituent for synthesis of many medicines and food supplements, where it has been associated with being a therapeutic agent for the cardiovascular system and immune system [1].

How does Tribulus terrestris work

Tribulus terrestris contains many important compounds, such as steroids, saponins, flavonoids, alkaloids, unsaturated fatty acids, vitamins and glutamic acid [2].

Extracts of tribulus are known to contain antioxidant, anti-apoptotic, anti-hypertension, anti-diabetic, anti-cancer and anti-fungal properties [3].

Benefits and Effects

Tribulus has a traditional history of use in for problems linked to the musculoskeletal, urogenital, gastrointestinal and central nervous systems [2]. Tribulus is also known to contain antibacterial, antifungal and anti-inflammatory effects [2].

Tribulus terrestris depression

A 400mg dose of methanol extract of tribulus was shown to have anti-depressant properties; this was highlighted through the restoration of antioxidants such as catalase, superoxide dismutase and malondealdehyde [4].

Tribulus terrestris blood pressure

Tribulus has been documented as treating high blood pressure [5]. Dry, aqueous tribulus extracts – dosage of 500mg of capsule form – were administered to patients suffering from Grade I essential hypertension [6].

Tribulus terrestris libido

Work seeking to better describe the efficacy of tribulus on sex hormones to grasp tribulus’s possible usefulness in treating erectile dysfunction (ED), demonstrated an increase in testosterone and DHT (dihydrotestosterone) [7].

Tribulus for men and women

Tribulus has also been reported to induce sexual arousal and desire in women [8]. A qualitative/quantitative study addressed the role of tribulus terrestris in treating female sexual dysfunction and found increased levels of DHEA (dehydroepiandrosterone), along with decreases in serum and free testosterone [9].

Tribulus terrestris kidney stones

Tribulus extract has been shown to inhibit the growth of calcium oxalate (CaOx) crystals [10]. Calcium oxalate crystals occur when there is a disproportionate ratio of urine waste to liquid. Another in vivo study addressed tribulus’ effect in renal tissue after induction of hyperoxaluria [11].

Tribulus and tongkat ali

Tongkat ali is said to possess anti-stress and anti-disease properties, and to improve physical strength [12].

Side effects of Tribulus terrestris

Although safety has been reported in the use of tribulus extract, there has been one reported case who after consuming tribulus terrestris showed acute kidney injury, hepatitis and seizure [13].

Also, studies on tribulus’ impact on atheletes confirmed that although tribulus had extra physiological benefits, it did have a negative effect on red blood cells, haemoglobin and thrombocyte indicies [14].

Tribulus dosage

Capsule (625mg powder), 3 times a day for 20 days – was reported as statistically increasing physical power in athletes [14]. In addition, it has been found that blood testosterone levels increased after 10 days of experimental administration of tribulus [Milasius et al., 2009], along with anaerobic alactic glycolytic power increases. [9].

Safe doses of tribulus in concentrations of 4mL per kg, have been found in 28-day long toxicity studies – no changes were noticed on biochemical, haematological and histological parameters [15].

Additional information

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  1. Saima Hashim, Tamana Bakht, Khan Bahadar Marwat and Asad Jan, 2014.Medicinal Properties, Phytochemistry and pharmacology of Tribulus Terrestris L. (Zygophyllaceae). Pakistan Journal of Botany, 46(1): 399-404.
  2. Lubna Fatima, Arshiya Sultana, Saad Ahmed, and Shabiya Sultana, 2015. Pharmacological Activities of Tribulus Terrestris Linn: A systematic Review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2): 136-150.
  3. Mrinmoy Gautam and Muthiah Ramanathan, 2018. Saponins of Tribulus terrestris attenuated neuropathic pain induced with vincristine through central and peripheral mechanism. Inflammopharmacology.
  4. Rupasri Dutt-Roy, E. Kayalvizhi and M. Chandrasekhar, 2017. Evaluation of the antidepressant activity of Tribulus terristris in Diabetic Depression in Rat Model. International Journal of Pharmaceutical Sciences and Research.
  5. Tunhai Xu, Yajuan Xu, Yue Liu, Shengxu Xie, Yunshan Si, Dongming Xu, 2009. Two new furostanol saponins from Tribulus terrestris L. Fitoterapia, 80: 354-357.
  6. Mohd Rizwan and Asim Ali Khan, 2014. Assessment of efficacy of Sankhahuli (Convolvulus pluricaulis Chois.) and gokhru (Tribulus terrestris L.) in the management of hypertension. Indian Journal of Traditional Konwledge, 13(2): 313-318.
  7. Kalamegam Gauthaman, Adaikan P. Ganesan, 2008. The hormonal effects of Tribulus terrestrial and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat. Phytomedicine, 15: 44-54
  8. V.K. Neychev, V.I. Mitev, 2005. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. Journal of Ethnopharmacology, 101: 319-323.
  9. Carlos R.B. Gama, Ricardo Lasmar, Gustavo F. Gama, Camila S. Abreu, Carlos P. Nunes, Mauro Geller, Lisa Oliveira and Alessandra Santos, 2014. Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction. Clinical Medicine Insights: Women’s Health, 7: 45-50.
  10. A. Aggarwal, S. Tandon, S. K. Singla, C. Tandon, 2010. Diminution of Oxalate Induced Renal Tubular Epithelial Cell Injury and Inhibition of Calcium Oxalate Crystallization in vitro by Aqueous Extract of Tribulus terrestris. Basic and Translational Urology, 36(4): 480-489.
  11. P. Kamboj, M. Aggarwal, S. Puri, and S.K. Singla, 2011. Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats. Indian Journal of Nephrology, 21(3): 154-159
  12. . I. B. M. Tambi, M. K. Imran, R. R. Henkel, 2011. Standardised water‐soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late‐onset hypogonadism? International Journal of Andrology.
  13. Azita Hajhossein Talasaz Mohammad-Reza Abbasi Saeed AbkhizSimin Dashti-Khavidaki, 2010. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrology Dialysis Transplantation, 25(11).
  14. K. Milasius, R. Dadeliene, Ju. Skernevicius, 2009. The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athlete’s organism homeostase.
  15. Surender Singh,  Rohit Kumar,  Ritu Karwasra,  Prerna Kalra,  Shalu Rani,  Debadatta Nayak,  YK Gupta, 2014. Evaluation of safety profile of homoeopathic mother tinctures. Indian Journal of Homeopathy, 8:81-86.
Also known as:Tribulus Terrestris
Type:General Health Supplement
Good for: , , , , , , ,
Stacks well with: D Aspartic Acid,DHA Softgels,Piracetam,Semax,Noopept,MACA,Shilajit,L-Citrulline Malate,Magnesium Bisglycinate Chelate,Centrophenoxine,Guggul Gum Resin,Magnesium Citrate,Milk Thistle,Taurine,DHEA,Vinpocetine,Best Nootropic Stack,Picamilon,L-Theanine,Triacetyluridine (TAU),Creatine,Rhodiola Rosea,Nootropics Sampler,Aniracetam,Turmeric,Ashwagandha,Sulbutiamine,Huperzine A,Encapsulation Kit,Zinc Gluconate,Modafinil,St. John’s Wort (Hypericum perforatum),Phosphatidic Acid,TUDCA,Yohimbine,Etizolam,Beta Ecdysterone,Synephrine,Lion’s Mane Mushroom,PRL-8-53,Fucoxanthin,L-Theanine Capsules,Artichoke Extract and Forskolin,Caffeine,Methylene Blue,Tongkat Ali,Epicatechin,Tianeptine Sodium,Uridine,Valerian Root,ALCAR Capsules,Raspberry Ketones,Theobromine,Spirulina,Quercetin Dihydrate,Melatonin Powder,Conjugated Linoleic Acid (CLA),L-Arginine,Rutaecarpine,Glucosamine Sulfate Potassium,Avena Sativa,Tianeptine Oxalate,NALT,Pramiracetam,Methylsulfonylmethane,Adrafinil,Citicoline,Sarcosine,Cissus Quadrangularis,DMAE Bitartrate,IDRA-21,Agmatine Sulfate,Cordyceps Mushroom,PEA (Phenylethylamine HCL),Dihydromyricetin,Tianeptine Sulfate,ALCAR,GABA,Instantized BCAA,Alpha GPC,Chromium Picolinate,Theacrine (Teacrine),Broccoli Sprout Extract,Aniracetam Capsules,Piperine Black Pepper,Mucuna Pruriens,5-HTP,Vitamin B12,Choline Bitartrate
Typical dose:1 capsule (625mg powder), 3 times a day for 20 days
Half Life :8 hours