Tianeptine Sulfate



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Tianeptine Sulfate

Anxiety Support
Depression Support
Improve Memory
Mental Health
Mood Support


We all have days when we are down in the dumps. For some, it only lasts a short time; however, for others, it continues and turns into a deeper depression.

If having either short or extended depression sounds like you or someone you know, perhaps you were able to control it with counseling, taking anti-depressants, or other methods.

There are many types of anti-depressants and they work differently from person to person. Therefore, it’s not unusual for a doctor to try numerous types before finding one that works for you.

One supplement that is getting tons of attention is tianeptine sulfate. Tianeptine sulfate provides wellbeing, better mood, improved cognitive, and an overall good feeling.

Whether tianeptine sulfate’s for short-term use or for long-term, it can be effective for both.

We will discuss tianeptine sulfate’s brain related benefits, how it works, the dosage, side effects, stacks, and other conditions tianeptine affects. [1]

Tianeptine Sulfate Effects and Benefits

Tianeptine sulfate is classified as a selective serotonin reuptake enhancer (SSRE) used to treat depression. [2] However, it can be put into various categories as well. Although much research is yet to be completed, it is promising to be very effective in many other ways, including:

Depression, stress, and Neuroplasticity – Neuroplasticity is the brain’s ability to adapt and change when learning; therefore, if neuroplasticity is increased, it contributes to better cognitive performance and improved ability to learn. [3] [6]

If it is decreased, the opposite effects occur. Depression can contribute to decreased neuroplasticity; therefore, it impacts the brain’s performance. Tianeptine sulfate improves neuroplasticity and decreases depression. [7]

Posttraumatic Stress Disorder(PTSD) – a study of 90 patients with PTSD showed positive results with the use of tianeptine sulfate. [4]

Panic Disorder – Studies have shown that with treatment with tianeptine sulfate and significant reduction in panic disorder. [5]

Memory – AMPA receptor activation supports synaptic connections. In simple terms, this means it helps to make newly learned facts and tasks more permanent improving long-term memory. [13]

Seizures – tianeptine sulfate may have the ability to suppress seizures. A1 receptors normally increase activity; therefore, reducing and raising the thresholds of seizures. [17]

Mood and brain activity – tianeptine intensifies the affect of some receptors in the central nervous system and modestly enhances the release of dopamine resulting in improved mood and brain activity.

Anxiety  and Panic Disorder– tianeptine sulfate given to elderly patients has shown to improve anxiety neurocognitive function.[15]

Parkinson’s disease – Many  animal and human studies have been conducted on the treatment of Parkinson’s disease with tianeptine sulfate and have had promising results in improving mental health scores. [16]

Anti-inflammatory and Pain – Studies have already concluded that tianeptine sulfate has anti-inflammatory abilities. [7]. Many people claim to get relief from the pain associated with fibromyalgia when taking tianeptine sulfate.

Attention-deficit hyperactivity disorder treatment (ADHD) – A preliminary study of 68 outpatients with ADHD concluded that the mean scores improved significantly and that tianeptine is beneficial in enabling better attention abilities and decreased hyperactive behaviors.  [13]

Irritable Bowel Syndrome treatment(IBS) – 228 patients had relief from IBS at 4 weeks into a study with less pain, stool frequency, a better quality of life, and overall satisfaction with Tianeptine treatment. [10]

Asthma treatment – Many people claim to receive relief from asthma with tianeptine sulfate. The Institute of Experimental Medicine in Caracas conducted a 52-week randomized trial of children with asthma. The ones that were given tianeptine had a major increase in lung function.[11]

Erectile dysfunction (ED) – Although more research is required, a study of 237 men with ED determined that tianeptine could be an effective therapy. [19]

How Does Tianeptine Work?

You could say that tianeptine is a multitasking drug and is frequently referred to as a Smart Drug. Technically, it’s a tricyclic antidepressant (TCA); however, it has a dissimilar drug profile than other TCAs; therefore, it is not typically grouped with them.

Tianeptine is not as well-known as many other anti-depressants. It was developed in France in the 1960s and used throughout the last part of the 2000s, when for some time, it took a back seat to other antidepressants such as MAOIs and SSRIs.

It has made a comeback, largely because it works well and doesn’t possess some of the side-effects of other antidepressants. Additionally, it can require smaller dosages than other antidepressants.

Animal and human studies have shown that a tianeptine sulfate nootropic for depression, bipolar disorder, anxiety, and severe depression and are very effective for many other illnesses. (8).

Tianeptine Sulfate VS Sodium

Tianeptine comes in basically three forms, tianeptine sodium, sulfate, and free acid. Many people have asked about the difference between tianeptine sodium and sulfate.

Doctors typically prescribe tianeptine in sodium form; however, it processes faster in the body and the effects only last about three hours.

It takes much longer for sulfate to be absorbed by the body making its effects last longer, about six hours or twice as long as sodium.

Tianeptine Free Acid VS Sulfate

Tianeptine free acid has the same benefits as sulfate. The difference is its half-life and dosage, described below.

Tianeptine Free Acid VS Sodium VS Sulfate

Tianeptine sulfate and acid free have the same structure but sulfate has twice the half-life as the other two. It only takes about 15 minutes for tianeptine sodium to cross the blood-brain barrier as opposed to around 45 minutes for free acid.

Lastly, tianeptine sodium has a much higher concentration than free acid, meaning that lower amounts are required to achieve the same effects – tianeptine sodium is approximately 5 times as potent as the free acid.

It just depends on an individual’s needs, preferences, and the reason they are taking the drug.

Tianeptine Sulfate Dosage

The question of how to take tianeptine sulfate frequently arises. More research must be conducted before knowing the exact answer to that question. Below is a general reference to the dosage.

Tianeptine sulfate comes in capsule or powder form. It is recommended to start with a low dosage and increase by small amounts until the correct dosage for you is attained. Sulfate powder usage is frequently for research purposes.

Tianeptine sulfate dosage is typically 25 mg once or twice a day. Many people report that Tianeptine sulfate’s half-life is about 6 hours. In addition, it does not have the usual severe crash as some drugs.

Even when starting with a low dosage, it’s best to limit it to 2 or 3 days a week with at least 3 – 4 days in between, especially when you first begin taking the drug. [18]

Additionally, taking smaller doses reduces the potential for addiction, severe withdrawals, and tolerance.

At lower doses, some say you can feel the relaxing effect without losing physical energy. Doses of 50 – 75 mg can be stimulating which may or may not be the result you are seeking. [18]

Tianeptine sulfate recreational use can be a problem due to the euphoric feeling that is sometimes experienced. A tianeptine sulfate recreational dose of over 100 mg may cause a tianeptine sulfate high sensation.

When taking higher doses of tianeptine sulfate, withdrawal may occur when the drug is stopped.

Frequently Asked Questions

How long does it take tianeptine sulfate to kick in?

The answer to that question depends on each person and also how much is taken. Many do not feel it kick in at all, but experience it as gradual, where one day they realize they are feeling better.

Other people say it takes about 10 – 30 minutes to feel a tianeptine sulfate buzz.

Are there any tianeptine sulfate interactions?

Do not take tianeptine within 14 days before or after taking MAOIs.

Where is the best place to buy tianeptine sulfate?

There are many places to buy it online. Many people prefer powdercity.com, which has a huge selection of quality products.

If you are seeking the cheapest place to buy tianeptine sulfate, powdercity.com also has some of the best prices.

Can you drink alcohol while taking tianeptine?

Combining tianeptine sulfate and alcohol is not recommended because it can lead to stronger hangovers than usual. Also, with tianeptine sulfate, alcohol can increase liver toxicity with extended use.

How can I taper off tianeptine?

Tianeptine sulfate has a gradual ramp up and ramp down and doesn’t has less withdrawal symptoms that other tianeptine . Additionally, it’s easier to adjust the dosage when tapering off.

Is tianeptine for sleep?

That is not typically its principal purpose, but some people are able to finally sleep when taking tianeptine; therefore, it could be useful for someone who needs a sleep aid. Some people desire a tianeptine sulfate sleep and some do not. Again, it works in different ways with each person.

Can you snort tianeptine?

Sure, you can, but please don’t, it’s definitely not recommended. Most people who are snorting tianeptine sulfate are using it for recreation purposes and it’s much easier to become addicted if you snort it.

If you have this type of questions about tianeptine sulfate, reddit.com is a place where you can ask questions and talk with other people who have personal experiences of this type.

Can you take tianeptine sulfate and LSD?

It’s definitely not recommended to combine a hallucinogenic with tianeptine sulfate. More research must still be completed to answer that and other questions.

Can you stop smoking with tianeptine?

Many people are able to stop smoking with tianeptine sulfate. Doctors frequently prescribe an anti-depressant for people who want to stop smoking to ease the stress.

Side Effects of Tianeptine Sulfate

Normally, there are no significant side-effects and when it does happen, they are minor. Furthermore, they are thought to have fewer side-effects than other anti-depressants and could be safer. [2] Some that are possible are:

  • Dizziness
  • Insomnia
  • Headaches
  • Drowsiness
  • Dry mouth

Other side-effects that are possible, but rare:

  • Constipation
  • Vivid dreams
  • Low blood pressure
  • Addiction


Pregnant and nursing women should not take tianeptine until more studies have been conducted.

Tianeptine Sulfate Stacks

Tianeptine sulfate is a very effective drug on its own, but some people get better benefits by stacking it with other drugs. It depends on the purpose for which you are taking it.

Many people find that drinking coffee gives it a good energy boost. Below are a few other options:

Tianeptine sodium and sulfate – taking these two nootropics together can enhance the effects.

Aniracetam – this is an anxiety reducer and can lead to better cognition, focus, and motivation.

Phenylpiracetam – can increase memory, focus, and creativity. Athletes take it to enhance their performance.

Phenibut – having too much on your mind can cause stress and can distract you from what you want and need to accomplish and initiates the inability to think straight. Phenibut can clear your mind, improve decision making and motivation. Again, Phenibut is frequently taken by athletes.

Closing Words

Tianeptine sulfate is having great results in reducing depression; however, studies are continually finding many more exceptional uses. In addition to their products, PowderCity has interesting and educational information that is useful as well.

Additional information

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  1. https://www.ncbi.nlm.nih.gov/pubmed/2902922
  2. https://www.ncbi.nlm.nih.gov/pubmed/11463130
  3. https://www.ncbi.nlm.nih.gov/pubmed/26142691
  4. https://www.ncbi.nlm.nih.gov/pubmed/16329631
  5. https://www.ncbi.nlm.nih.gov/pubmed/15582922
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701287/
  7. https://www.ncbi.nlm.nih.gov/pubmed/18072812
  8. https://doi.org/10.2165/00003495-199549030-00007
  9. https://www.tianeptine.com/ibs/index.html


  1. [2] R. Sapolsky, Biology and Human Behavior: The Neurological Origins of Individuality, 2nd ed. The Teaching Company, 2005.
  2. B. S. McEwen, S. Chattarji, D. M. Diamond, T. M. Jay, L. P. Reagan, P. Svenningsson, and E. Fuchs, “The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation,” Mol. Psychiatry, vol. 15, no. 3, pp. 237–249, Mar. 2010.
  3. https://www.ncbi.nlm.nih.gov/pubmed/26142691
  4. https://www.ncbi.nlm.nih.gov/pubmed/17457538
  5. D. Elmenhorst, P. T. Meyer, O. H. Winz, A. Matusch, J. Ermert, H. H. Coenen, R. Basheer, H. L. Haas, K. Zilles, and A. Bauer, “Sleep deprivation increases A1 adenosine receptor binding in the human brain: a positron emission tomography study,” J. Neurosci. Off. J. Soc. Neurosci., vol. 27, no. 9, pp. 2410–2415, Feb. 2007.
  6. http://www.a1b2c3.com/Tianeptine-001.html#dosage
  7. https://www.jsm.jsexmed.org/article/S1743-6095(15)31384-9/fulltext
Also known as:Tianeptine Hemisulfate Monohydrate, Tianeptine Sulphate
Good for: , , , , , , , ,
Stacks well with: Picamilon
Typical dose:40mg once daily
Half Life :6 - 12 hours