Cissus Quadrangularis

8.7

Bone Health

9.0 /10

Libido

8.0 /10

Muscle Mass

9.0 /10

Cissus Quadrangularis

Bone Support
Heart Health
Immune Support
Joint Health
Post Workout
Pre Workout
Weight Loss
sexual health

Description

Summary

Cissus quadrangularis (Linn) [1] is a common medicinal plant that has long been found in Africa and Asia for over a century [2]. Stems and leaves extracts from Cissus has been used in food preparation and as a raw drug in India for the treatment of various diseases [2].

Benefits and Effects  

Cissus stem and leaves have been used for the treatment of indigestion, dyspepsia, bone fractures, along with diarrhoea and haemorrhoids [3], [4], [5]. Cissus is involved with fracture healing, antibacterial and anti-hemorrhoidal activates [5].

Bone fractures and tendon restoration

Cissus has been previously reported to relieve pain in patients suffering from Osteoarthritis, in which Cissus was associated with producing prostaglandins [6]. Cissus has been noted as showing beneficial effects on bone – improving the healing process in bone fractures [7].

One study reported Cissus as a plant agent possessing regenerative and anti-inflammatory properties – to elicit protection and regenerate articular cartilage [6].

Cissus also has also been reported to protect and restore muscles and tendons [8], [9].

Obesity and weight loss 

One study showed significant decreases in serum lipids and glucose along with significant increases in plasma serotonin and creatine levels, using Cissus. [10]

Another study evaluating the effects of Cissus on weight loss in 72 obese people, found considerable waist size reduction after 10 weeks. Also, when combined with Irvingia gabonensis, a synergistic effect was reported; decrease of total cholesterol, LDL-cholesterol, and fasting blood glucose (when compared to Cissus quadrangularis) [11].

Extracts

The ethanol extract of Cissus contains therapeutic benefits. In this example, an ethanol extract was shown to induce anabolic and osteogenic properties [12].

Cissus contains many beneficial extracts that have been said to possess pharmacological action 13], with stem, leaf and root extracts having properties considered crucial in managing various ailments [14].

Dosage

For haemorrhoid treatment, a dosage schedule of 2x, 500mg capsules, dry powder form, were recommended twice daily as an effective treatment for haemorrhoid pain and inflammation, along with haemorrhoid size reduction [15]. However, this study is not conclusive, and data remains unclear for haemorrhoid improvement [16].

A large clinical study of Cissus (Linn) reported that Cissus dosage varies depending on what is being treated – within the clinical setting being investigated [16].

Side effects

It should be noted that as clinical studies investigating the benefits of Cissus extracts and formulations are still being determined, there have been no studies demonstrating that Cissus has anabolic and body building activities [17].

Safety in Cissus extracts has been reported as “exceedingly safe” [17] and there are filed patent applications for Cissus extracts [17].

 

Additional information

Weight0.161 kg

Reviews

There are no reviews yet.

Be the first to review “Cissus Quadrangularis”
Sources

Sources

  1. Srinivasa Rao Sirasanagandla, Sreedhara Ranganath Pai Karkala, Bhagath Kumar Potu, and Kumar M.R. Bhat, 2014. Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type I Diabetes Mellitus in Male Wistar Rats.
  2. Hae Jin Lee, Bao Le, Dong-Ryung Lee, Bong-Keun Choi, Seung Hwan Yang, 2018. Cissus quadrangularis extract (CQR-300) inhibits lipid accumulation by downregulating adipogenesis and lipogenesis in 3T3-L1 cells.
  3. Anoop Austin, R. Kannan and M Jegadeesan, 2004. Pharmacognostical studies on Cissus quadrangularisL. variant I and II.
  4. K.N. Chidambara Murthy, A. Vanitha, M. Mahadeva Swamy, and G.A. Ravishankar, 2003. Antioxidant and Antomicrobial Activity of Cissus quadrangularisL
  5. Neha Agrawal and Manju Jain, 2018. Spectrophotometric and chromatographic analysis of Cissus quadrangularisfrom region.
  6. Jagat R. Kanwar, Rasika M. Samarasinghe, Kuldeep Kumar, Ramesh Arya, Sanjeev Sharma, Shu-Feng Zhou, Sreenivasan Sasidharan, Rupinder K. Kanwar, 2015. Cissus quadrangularisinhibits IL-1beta induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomised rats via p38 MAPK signalling
  7. Jameela Banu, Erika Varela, Ali N. Bahadur, Raheela Soomro, Nishu Kazi and Gabriel Fernandes, 2012. Inhibition of Bone Loss by Cissus quadrangularisin Mice: A Preliminary Report.
  8. S. Kavitha and G. Manimekalai, 2015. A study of Cissus quadrangularisplant – a review.
  9. Udeme John Dickson, Igbe Igbodaro and Edema, Mary Olire, 2012. Antibacterial and antifungal activity and Bone Healing Potency of methanol extract of Cissus argutaHook F.
  10. Shirin Hasani-Ranjbar, Neda Nayebi, Bagher Larijani, Mohammad Abdollahi, 2009. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity.
  11. Julius E Oben, Judith L Ngondi, Claudia N Momo, Gabriel A Agbor, and Caroline S Makamto Sobgui, 2008. The use of Cissus quadrangularis/Irvingia gabonesiscombination in the management of weight loss: a double-blind placebo-controlled study.
  12. Raazia Tasadduq, Jonathan Gordon, Khalid A Al-Ghanim, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Abdul Rauf Shakoori, 2017. Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralisation of Murine Pre-Osteoblastic MC3T3-E1 Cells.
  13. Garima Mishra, Surabh Srivastava, B.P Nagori, 2010. Pharmacological and Therapeutic Activity of Cissus quadrangularis: An Overview.
  14. Bhagath Kumar Potu, Muddanna S Rao, Gopalan Kutty N, Kumar MR Bhat, Mallikarjuna Rao Chamallamudi, Soubhagya Ranjan Nayak, 2008. Petroleum Ether Extract of Cissus quadrangularis(Linn) Stimulates the Growth Fetal Bone During Intra Uterine Developmental Period: A Morphometric Analysis.
  15. Ampai Panthong, Wanicha Supraditaporn, Duangta Kanjanapothi, Tawat Taesotikul, Vichai Reutrakul, 2007. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.
  16. Ratree Sawangjit, Panupong Puttarak, Surasak Saokaew and Nathorn Chaiyakunapruk, 2017. Efficacy and Safety of Cissus quadrangularis L. in Clinical Use: A Systematic Review and Meta-analysis of Randomised Controlled Trials.
  17. Sidney J. Stohs, and Sidhartha D. Ray, 2013. A Review and Evaluation of the Efficacy and Safety of Cissus quadrangularisExtracts.
Also known as:Harjor, Asthi Shrinkhala, Bone Setter
Type:Joint Relief
Good for: , , , , , , ,
Stacks well with: Taurine
Typical dose:500 -1000mg daily
Half Life :Coming soon...
Cissus Quadrangularis

Cissus Quadrangularis

Bone Support
Heart Health
Immune Support
Joint Health
Post Workout
Pre Workout
Weight Loss
sexual health