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Perhaps the most widely used drug in the world, caffeine is a naturally occurring plant compound that belongs to a group of stimulants called methylxanthines.
Benefits and Effects
Caffeine temporarily increases alertness. In one study, a daily dose of 800mg improved reaction speed and accuracy in sleep deprived patients. 
Enhancing Athletic Performance
In a study of young male athletes, caffeine temporarily increased upper and lower body muscle strength by 6-13 percent.  In a study of female athletes, caffeine reduced perceived exertion and pain, which allowed them to increase their training volume. 
Controlling Weight Gain
By increasing metabolism and breaking down stored fat, caffeine can help with weight management. 
A moderate dose of 200-250mg can improve mood for up to three hours; however, larger doses may also increase anxiety.  
Preventing Parkinson’s Disease
Caffeine’s neuroprotective properties may help prevent Parkinson’s disease even in patients with a genetic predisposition.  
Lowering Risk for Dementia and Alzheimer’s
Caffeine suppresses production of amyloid beta, which is associated with Alzheimer’s.  Drinking 3-5 cups of coffee daily has been correlated with decreased dementia risk.  In one study, individuals who regularly consumed high to moderate doses caffeine consistently outperformed non-users on memory recall tests. 
Defending the Liver
In a study of patients with fatty liver disease, those who drank caffeinated coffee had less severe liver scarring than their non-coffee-drinking peers.  A dose of 100mg daily may also prevent liver tissue scarring in hepatitis C patients.  Drinking coffee can help prevent cirrhosis, but other sources of caffeine haven’t demonstrated the same benefit. 
Studies suggest that daily caffeine consumption may reduce your risks for oral, colon, skin and liver cancers.   
Caffeine’s antioxidant properties may help protect the skin from UV damage.  Topical creams consisting of 30 percent caffeine may reduce itchiness, scaling, redness and oozing in dermatitis patients. 
Alleviating Asthma Symptoms
Caffeine temporarily opens airways, which can help relieve symptoms of asthma and bronchitis. 
Detering Diabetes, Kidney Stones, Tinnitus and Gout
Moderate caffeine intake may lower women’s risk for developing type 2 diabetes.  Studies suggest that the same may be true for caffeine and kidney stones. Some people use caffeine for tinnitus and gout prevention treatment.   
How It Works
Caffeine stimulates the sympathetic nervous system by blocking adenosine receptors.  It also binds to phosphodiesterase receptors, which causes widening of blood vessels and breakdown of fat. 
Caffeine Anhydrous is a quickly absorbed molecule that efficiently transports throughout the body. Caffeine levels begin to rise as quickly as fifteen minutes after ingestion and don’t reach their peak until forty-five minutes later.
WARNING: Please follow dosage directions on the product label when supplementing with caffeine anhydrous.
Doses of 225-360mg tend to be most effective for enhancing physical performance while 100-600mg is the recommended range for improving mental performance.  Caffeine’s half-life is typically around five hours. 
Caffeine overdoses are uncommon, but caffeine poisoning is possible with amounts over 1 gram. Over 5 grams of caffeine is a lethal dose. Caffeine overdose symptoms include dehydration, nausea, fever, delirium and seizures. 
Caffeine’s side effects include restlessness, anxiety, light-headedness, flushed face and increased urination. Excitability as well as rambling thoughts and speech are also common. 
- Milk Thistle
L-theanine, which has become one of the more popular caffeine alternatives, can be combined with the real deal to enhance alertness and cognitive performance better than either substance alone. A study of healthy young adults found that taking 97mg of L-theanine and 40mg of caffeine together improved subjects’ ability to focus on complex cognitive tasks.