Summary

Dimethylaminoethanol (DMAE), is a chemical that is involved in a succession of reactions which forms acetylcholine. [1] [2]

Benefits and Effects

Brain fog

It is being reported that with DMAE, brain fog is significantly reduced. [3]

DMAE for Depression and Anxiety

A randomized, double-blind, placebo-controlled study was completed with 80 subjects with threshold emotional disturbances.

Increased energy 

DMAE leads to the production of acetylcholine, a very important neurotransmitter that aides the brain and nervous system. [4]

Skincare

DMAE is increasingly becoming an ingredient in cosmetics. Growing evidence is being attained about the ability of DMAE to improve skin. [5]

Athletic performance

Many athletes and bodybuilders claim it gives them improved recovery time and performance. The energetic effects of DMAE may enable them to have better stamina as well. [6] [7]

How It Works

Choline, produced by DMAE, is one of the most critical neurotransmitters for memory storage and retention. DMAE and choline are essential to the brain’s function. [8]

Dosage

DMAE comes in a very wide range of strengths ranging from 50 mg to 1500 mg. [9]

It may be advisable to start with 50 to 100 mg once or twice a day. That will let you test if the dosage is appropriate for you or if you have any side-effects. If you tolerate that dosage well but are not receiving any benefits, then increase it gradually until you find the correct dosage for you.

Many people are reporting that they are making homemade DMAE serum by mixing 3% or less of the liquid form with baby oil or other oils of their preference. They also mix a small amount with their favorite cream for moisturizing. [9]

Side Effects

In most studies and personal experiences, DMAE is well tolerated. [10]

• Insomnia
• Headache
• Restlessness
• Irritability
• constipation
• drowsiness
• itchiness
• confusion
• gastrointestinal problems
• high blood pressure
• depression

It is recommended that people with sensitive skin use it every other day until they know their tolerance. [11]

Contradictions

Women who are pregnant or nursing should avoid DMAE.

People with a history of convulsions, epilepsy, or bipolar disorder should consult a doctor before use.

On rare occasions, increased blood pressure can occur. People with high blood pressure should practice caution. [12]

Stacks

L-Tyrosine, DMAE, Lecithin, and Vitamin B6

DMAE and Tyrosine can enhance cognitive and physical effects. Lecithin increases good cholesterol and lowers triglycerides. [13]

A study was conducted with 50 people who instruct sports. They were given a combination of dimethylaminoethanol bitartrate, ginseng, minerals, and vitamins. The DMAE’s before and after results were much better in the subjects who took the stack as compared to a placebo. [14] [15]

DMAE Bitartrate and choline

These two supplements taken together may provide more oxygen to the brain which further supports healthy brain performance.

DMAE and Alpha GPC

This stack is recommended for increasing energy, cognition, growth hormones, and decreasing cognitive decline, and symptoms of Alzheimer’s disease. Alpha GPC aids choline in bypassing the blood-brain barrier. [16]