6.6 /10


6.0 /10


9.0 /10


Anxiety Support
Mental Health
Post Workout
Pre Workout
Sleep Quality
Weight Loss
Mood Support



Picamilon (nicotinyl-y-aminobutyric acid) was first synthesized in the Soviet Union, [1,2] and facilitates the absorption of GABA (Gamma-aminobutyric acid) by the human body.

How Picamilon Works

Picamilon consists of two metabolites: Niacin and GABA. GABA is an important amino acid that serves to transmit inhibitory impulses to the CNS. [5]

Picamilon activates GABA receptors, increasing blood flow to the brain. [13] This process facilitates more efficient delivery of oxygen and nutrients throughout the body, enhancing focus, alertness and motivation.

Picamilon, pre-workout, improves blood flow and oxygen consumption. The optimal picamilon dosage for sleep is less than 100 mg; higher doses are likely to cause sleep disturbances.

Picamilon Benefits and Effects

Picamilon can be used as nutritional support by individuals who wish to improve mood and energy levels. [5] Picamilon has also been shown to increase concentration and focus for many individuals[8]

Reducing Anxiety and Depression

Picamilon lowers anxiety by providing the brain with extra GABA [3] Picamilon is also believed to be an effective antidepressant. [4]

Improving Vision

Picamilon improved the vision of patients suffering from macular degeneration. [5] Likewise, picamilon supplementation has helped patients with central chorioretinal dystrophy better distinguish certain shapes and colors in addition to improving peripheral vision and reducing the severity of glaucoma. [6]

Enhancing Memory and Protecting the Brain

Rats fed picamilon showed improved short and long term memory. Additionally, picamilon prevented memory loss following electroshock treatments. [7] Picamilon increased mitochondrial functioning in brain cells of brain trauma rats. [8]

Picamilon also protects brain and immune cells from membrane damage and oxidative stress resulting from sleep deprivation. [9]

Promoting Blood Flow to the Brain

In a comparative study, picamilon was more effective than piracetam and vinpocetine at increasing blood flow to the brain. [10]

Treating Parkinson’s Disease

Picamilon stabilized serotonin and dopamine levels in rats with Parkinson’s disease. [11]

Preventing Inflammation of Nerves

In a study of diabetic rats, picamilon successfully reduced neuropathy, or nerve inflammation. [12]


In studies, 50-400 mg/day have proven effective for various conditions. Recommended adult dose is initially 50-100mg/day, increasing if needed to a maximum dose of 200mg in the morning and 100mg in the mid-afternoon.[8]

Picamilon capsules are available, along with picamilon sublingual lozenges. Picamilon powder is water soluble, mixing well with most beverages including juices and smoothies.

The effects of picamilon occur within 1 hour. 4-6 hours should be given between doses to allow picamilon to work.

Side Effects

Picamilon may cause mild dizziness and nausea. [14]. Allergic reactions and skin rashes occur rarely. In high doses, picamilon can cause drastic drops in blood pressure, which can be dangerous for users with hypotension. [15]

Avoid taking picamilon with other drugs that affect the GABA receptors. Mixing picamilon and alcohol is particularly dangerous because it can exacerbate the negative effects of both substances.

Avoid aspirin and uricosuric agents when taking niacin supplements. Picamilon bulk powder sometimes contains additives which may be allergenic.

In the US, there is no law prohibiting individual possession or consumption of picamilon. It can be purchased online.



  1. Norton W. Milgram, Heather Callahan and Christina Siwak, 1999. Adrafinil: A Novel Vigilance Promoting Agent.
  2. Christina T. Swiak, Heather Callahan and Norton W. Milgram, 2000. Adrafinil: Effects on Behaviour and Cognition in Aged Canines.
  3. https://en.wikipedia.org/wiki/Adrafinil
  4. http://enacademic.com/dic.nsf/enwiki/616907
  5. http://www.chemeurope.com/en/encyclopedia/Adrafinil.html
  6. Mosstafa Kazemi, Sami Sajjadifar, Abdelkarim Aydi, Mohammad Mirzaei Heydari, 2018. Biological and Pharmaceutical Organosulfur Molecules.
  7. https://pubchem.ncbi.nlm.nih.gov/compound/adrafinil#section=Pharmacology-and-Biochemistr
  8. https://www.lookchem.com/Adrafinil/
  9. R. Nageswara Rao, Dhananjay D. Shinde, M.V.N. Kumar Talluri, Sachin B. Agawane, 2008. LC-ESI-MS determination and pharmacokinetics of adrafinil in rats.
  10. Norton W. Milgram, Christina T. Swiak, Philippe Gruet, Patricia Atkinson, Frederique Woehrle and Heather Callahan, 2000. Oral Administration of Adrafinil Improves Discrimination Learning in Aged Beagle Dogs.
  11. Dongsoo Kim, 2012. Practical Use and Risk of Modafinil, A Novel Waking drug.
  12. MV Solbrig, GF Koob and WI Lipkin, 1999. Orofacial dyskinesias and dystonia in rats infected with Borna disease virus; a model for tardive dyskinetic syndromes.
  13. Ronald M. Kobayashi, 1976. Orofacial Dyskinesia. Clinical Features, Mechanisms and Drug Therapy.
  14. Stephane Thobois, Jing Xie, Helena Mollion, Isabelle Benatru and Emmanuel Broussolle, 2004. Adrafinil-Induced Orofacial Dyskinesia.
  15. Michael G. Tramontana, Ronald L. Cowan, David Zald, Jonathan W. Prokop, and Oscar Guillamondegui, 2014. Traumatic brain injury-related attention deficits: Treatment outcomes with lisdexamfetamine dimesylate (Vyvanse).
  16. David W. Goodman, 2010. Lisdexamfetamine Dimesylate (Vyvanse), A Prodrug Stimulant for Attention-Deficit/Hyperactivity Disorder.
  17. https://en.wikipedia.org/wiki/Prodrug
  18. Helene Bastuji and Michel Jouvet, 1988. Successful Treatment of Idiopathic Hypersomnia and Narcolepsy with Modafinil.
  19. Antonio Osorio-Lozada, Thomas Prisinzano and Horacio F. Olivo, 2004. Synthesis and determination of the absolute stereochemistry of the enantiomers of adrafinil and modafinil.
  20. https://www.drugsand.me/en/modafinil/
  21. Dubey S, Ahi S, Beotra A, Reddy IM, Kaur T, Jain S, 2008. A novel study of mass spectrometric fragmentation of adrafinil, modafinil and their metabolite modafilinic acid under ESI-LC-MS/MS and EI-GC-MS.
  22. https://psychonautwiki.org/wiki/Adrafinil
  23. Geraldine Dowling, Pierce V. Kavanagh, Brian Talbot, John O’Brien, Gary Hessman, Gavin McLaughlin, Brendan Twamley, and Simon D. Brandt, 2016. Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog. Drug Testing and Analysis.
  24. K. Deventer, K. Roels, F.T Delbeke, P. Van Eenoo, 2011. Prevelance of legal and illegal stimulating agents in sports.
  25. Solveiga Grinberga, Liga Zvejniece, Edgars Liepinsh, Maija Dambrova and Osvalds Pugovics, 2008. Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography-tandem mass spectrometry.
  26. Seth Sankary, Peter Canino, Jennifer Jackson, 2016. Phenibut Overdose. American Journal of Emergency Medicine.
  27. V.V. Bagmetova, A.N. Krivitskaya, and I.N. Tyurenkov, 2015. Effects of Phenibut and Citrocard on Non-Competitive and Competitive Behaviour during Provoked Aggression in Animals. Bulletin of Experimental Biology and Medicine.
  28. Izyaslav lapin, 2001. Phenibut (beta-Phenyl-GABA): A Tranquilizer and Nootropic Drug.
  29. Carl L Hansen, Scott H. Burton, Christophe Giraud-Carrier, Josh H. West, Michael D. Barnes, and Bret Hansen, 2013. Tweaking and Tweeting: Exploring Twitter for Nonmedical Use of a Psychostimulant Drug (Adderall) Among College Students.
  30. Rohini R. Vanga, Bikram Bal, and Kevin W. Olden, 2013. Adderall Induced Acute Liver Injury: A Rare Case and Review of the Literature.

Also known as:Pikamilon, Pycamilon, Nicotinoyl-GABA
Good for: , , , , , , , , ,
Stacks well with: Adrafinil
Typical dose:50 - 400mg
Half Life :3 - 6 Hours