Phenibut

Phenibut

8

Anxiolytic

8.0/10

Motivation

7.0/10

Memory

9.0/10

Phenibut

SKU: PHEN
Anxiety Support
Boost Energy
Bulk Powder
Improve Focus
Improve Memory
Mental Health
Mood Support
Nootropics

Description

Summary

Phenibut is a synthetic central nervous system depressant used to treat a number of psychological conditions including depression, anxiety, addiction and posttraumatic stress disorder. [1]

Dependency and withdrawal symptoms have been reported in individuals who take more than the recommended dosage, so limit your use to avoid phenibut addiction. [2]

Benefits and Effects

Promoting Healthy Brain Functions

Phenibut improved blood flow in the brains of rats, which resulted in reduced motor and sensory deficiencies related to stroke. [3] [4] It also decreased symptoms of amnesia in rats exposed to high voltage shocks. [5] In addition to alleviating nerve pain, phenibut appears to defend neuroblastoma cells against hydrogen peroxide damage. [6] [7]

Boosting Cognitive Capacity

For example, phenibut speeds up animals’ defensive reflexes and increases brain responses to stimuli, which improves overall learning capacity. [8] [9] Phenibut has also demonstrated effectiveness at improving amnesia and passive avoidance conditioning. [10] [11]

Promoting Relaxation

Phenibut is able to promote relaxation without drowsiness. [37]

Nootropic Benefits

In passive avoidance tasks, Phenibut showed enhanced learning and memory. [34] It also enhanced the performance of mice during swimming and rotating rod tests. [34].

Mood

During a forced swim test, Phenibut reduced immobility time to a significant degree. [36] Scientists use forced swim tests to measure activity related to enhanced mood. [38, 39]

Sleep Quality

One study suggests this is because it may activate dopaminergic processes which cause sedation. [34]

Anxiety

Phenibut reduces fear and anxiety in animals. [12] [13] Phenibut also makes rats less aggressive. [14]

Protecting the Heart

In combination with nitric oxide, phenibut reduces heart rate and contractility in animals under stress. [15] [16] When paired with nicotinic acid, phenibut can prevent blood flow disturbances in animals following a stroke. [17]

Curbing Alcohol Abuse

In one study, phenibut decreased alcohol-dependant rodents’ urges to drink while protecting their bodies from alcohol-related damage. [21] [22]

Immune Defense

Phenibut has proven helpful in controlling overactive immune systems and restoring suppressed immune systems by replenishing phagocytic cells . [23] [24]

Improving Respiratory Issues

Phenibut injections stopped sleep apnea in rats. [25] It also increased breathing capacity during emotionally stressful situations. [26]

How It Works

Unlike GABA, Phenibut HCL can cross the blood-brain barrier (BBB). [34] This is due to the addition of a phenyl ring to its basic structure. [34]

Phenibut was designed to resemble a chemical called gamma-aminobutyric acid, or GABA. The human brain naturally creates GABA, which produces a calming effect on the body. [27] The addition of a phenyl group in phenibut allows supplemental GABA to cross the blood-brain barrier. [28]

Dosage

However, unlike antidepressants such as SSRIs, phenibut shouldn’t be taken every day.

Begin using small dosages. Phenibut online user reviews, report daily targets of 250-1000mg, but starting at a high dose can lead to unpleasant feelings of drunkenness often referred to as “phenibut high.”

Side Effects

Some people who take phenibut experience mild side effects like headache and increased depression, [30] anxiety, irritability, lightheadedness, insomnia, fatigue, reduced appetite, muscle spasms, heart palpitations and hallucinations. [32] [33]

A phenibut overdose could also cause drastic drops in body temperature. [30]

Documented withdrawal symptoms include elevated  Due to its potential for abuse, phenibut should be taken with precaution.

Additional information

Weight0.036 kg

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Sources

Sources

1. http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf
2. https://www.erowid.org/references/refs_view.php?ID=8526
3. https://www.ncbi.nlm.nih.gov/pubmed/16878492
4. https://www.ncbi.nlm.nih.gov/pubmed/26621244
5. https://www.ncbi.nlm.nih.gov/pubmed/26906198

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6. https://www.ncbi.nlm.nih.gov/pubmed/26234470
7. http://www.fasebj.org/content/26/1_Supplement/672.6.short
8. https://www.ncbi.nlm.nih.gov/pubmed/19476215
9. https://www.ncbi.nlm.nih.gov/pubmed/15776965
10. https://www.ncbi.nlm.nih.gov/pubmed/26906198
11. https://www.ncbi.nlm.nih.gov/pubmed/20396730
12. https://www.ncbi.nlm.nih.gov/pubmed/17944107
13. https://www.ncbi.nlm.nih.gov/pubmed/19899708
14. https://www.ncbi.nlm.nih.gov/pubmed/26033589
15. https://www.ncbi.nlm.nih.gov/pubmed/27017698
16. https://www.ncbi.nlm.nih.gov/pubmed/14558346
17. https://www.ncbi.nlm.nih.gov/pubmed/22702103
18. https://www.ncbi.nlm.nih.gov/pubmed/12025796
19. https://www.ncbi.nlm.nih.gov/pubmed/16995433
20. https://www.ncbi.nlm.nih.gov/pubmed/25432276
21. https://www.ncbi.nlm.nih.gov/pubmed/16047680
22. https://www.ncbi.nlm.nih.gov/pubmed/18225758
23. https://www.ncbi.nlm.nih.gov/pubmed/20597368
24. https://www.ncbi.nlm.nih.gov/pubmed/20432718
25. https://www.ncbi.nlm.nih.gov/pubmed/16579056
26. https://www.ncbi.nlm.nih.gov/pubmed/18607733
27. http://www.sciencedirect.com/science/article/pii/S001429990800068X
28. http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf
29. https://www.erowid.org/references/refs_view.php?ID=8526
30. http://www.amjmed.com/article/S0002-9343(14)00284-8/abstract
31. https://www.ncbi.nlm.nih.gov/pubmed/26114346
32. http://www.tandfonline.com/doi/abs/10.3109/14659891.2012.668261?journalCode=ijsu20
33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604470/
34. http://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x/pdf
35. https://books.google.com/books?id=_iMDQOA2UIsC&pg=PA25#v=onepage&q&f=false
36. http://books.google.com/books?id=MFppbhSMygIC&pg=PA209#v=onepage&q&f=false
37. https://www.ncbi.nlm.nih.gov/pubmed/15609067
38. http://www.research.psu.edu/arp/experimental-guidelines/rodent-behavioral-tests-1/porsolt-forced-swim-test
39. https://books.google.com/books?id=ZYqoBgAAQBAJ&pg=PA186#v=onepage&q&f=false
Also known as:Fenibut, Phenybut, Beta-Phenyl-GABA
Type:Anxiolytic
Good for: , , , , , , , ,
Stacks well with: Phenylpiracetam,Sulbutiamine
Typical dose:250mg
Half Life :5.3 Hours