Agmatine Sulfate


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Agmatine Sulfate

Boost Energy
Bulk Powder
Heart Health
Improve Focus
Improve Memory
sexual health
Mood Support



Agmatine is a neurotransmitter derived from the amino acid L-arginine, it is typically found within the neurons.[1]

Benefits & Effects

Improves depression

Research discovered that agmatine sulfate has the capacity to reduce anxiety and elevate mode.[2]

Reduces Cortisol, Anxiety and Stress

Although the body naturally produces cortisol, long term overexposure can have negative consequences and increase the risk of health problems such as:

  • Weight gain
  • Sleep problems
  • Concentration and memory impairment
  • Heart disease
  • Digestive problems
  • Anxiety
  • Depression [3]

Since it assists in reducing anxiety, it helps the brain cope with stress which limits the production of the stress hormone cortisol.[4]

Stroke prevention and healing

Studies has found that Agmatine may protect the body against stroke by dilating the blood vessels in the brain to increase blood flow.[5]

Stimulate muscle growth

Testosterone levels are increased by high levels of LH. This creates the best hormonal environment for muscle growth and improved athletic performance.[6],[7]

Agmatine sulfate erectile dysfunction

Agmatine enhances sex drive and improves erectile dysfunction.[8]

Epilepsy and Seizures

Studies also suggest that agmatine enhances the effects of antiepileptic drugs such as valproate and phenobarbital.[9]

Protects the kidneys

Agmatine may improve the overall function of the kidneys by accelerating the blood filter rate of the kidneys. [10]

Type 2 Diabetes

Agmatine stimulates the pancreas so that it produces insulin; and, studies suggest that agmatine might be a positive addition to type 2 diabetes treatment.[11]

Agmatine and Other Supplements

Agmatines action on nitric oxide is an indication that it contains ingredients that boost heart pressure, heart rate and vascularity. Do not combine agmatine with products:

  • D-Aspartic Acid
  • Creatine
  • Rauwolscine
  • Yohimbine
  • L-Citrulline
  • L-Arginine [12]

Growth hormone boosters work well with agmatine, they provide a greater ergogenic enhancement.[13]


Apart from minor side effects, there have been no reported casualties from ingesting agmatine. Agmatine is intended for healthy adults over the age of 18. Consult your physician before taking agmatine if you suffer from, or have suffered from any of the following conditions:

  • Prostate enlargement
  • Diabetes
  • Psychiatric disease
  • Seizure disorder
  • Thyroid disease
  • Kidney disease
  • Liver disease
  • Heart disease
  • Stroke
  • Cardiac arrhythmia
  • High or low blood pressure [14]

Pregnant or nursing women should not take agmatine; you should also stop using the product 2 weeks before an operation.[15]

It should not be used in combination with erectile dysfunction medication.[16]

Side Effects

Trial participants were given low doses of agmatine. Three reported gastrointestinal disruptions such as vomiting, nausea and diarrhoea. One participant dropped out of the trial due to the negative side effects.[17]

Agmatine increases appetite; however, this is beneficial for those who want to gain weight or bulk up.[18]

If you suffer from low blood pressure, agmatine can reduce it even further.[19]


Manufacturers recommend taking between 750mg to 2.5g per day.[20]

When to take agmatine sulfate

To fully experience the nitric oxide boosting effects, the best time to take it is 15-30 minutes before exercise.[21]

How to take agmatine

Agmatine should be taken on an empty stomach or either 30 to 60 minutes before or after consuming protein. Health experts recommend rotating your intake of agmatine to avoid building up a tolerance. It is advised that you take the product for three days and then take one day off.[22]

Additional information

Weight0.101 kg


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  12. John E. Piletz, Sounder Regunathan, Paul Ernsberger: Agmatine and Imidazoline. New York Academy of Sciences: 2003.
  13. John E. Piletz, Sounder Regunathan, Paul Ernsberger: Agmatine and Imidazoline. New York Academy of Sciences: 2003.
Also known as:(4-aminobutyl)guanidine
Good for: , , , , , , ,
Stacks well with: Creatine,Alpha GPC
Typical dose:750mg to 2.5g per day
Half Life :2 hours