Agmatine Sulfate


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Agmatine Sulfate

Boost Energy
Bulk Powder
Heart Health
Improve Focus
Improve Memory
sexual health
Mood Support



Agmatine is a neurotransmitter derived from the amino acid L-arginine, it is typically found within the neurons.[1] Microbes in the gut produce the highest levels of agmatine, it is also produced in small amounts by the mitochondria in the liver.[2] Agmatine is also found in fermented foods and drinks such as meat, fish, vegetables, cereals, dairy products, wine, beer and coffee. However, the volume is so low that it is not possible to get beneficial amounts from these products,[3] which is why users take agmatine sulphate as a supplement in powder or capsule form.

Agmatine pump and agmatine sulphate pump are popular names for the supplement because they are typically used as a workout booster. However, as shall be discussed, there are many other benefits associated with the product.

Benefits & Effects

Lowers blood glucose: Imidazoline receptors assist in regulating the sympathetic nervous system which reduces blood pressure and blood glucose levels. Agmatine activates imidazoline receptors. Once blood pressure has been reduced, there is an increase in ?-endorphin which speeds up the process of glucose being transferred to the muscle tissue, this takes place even when the body is in a state of rest. Studies have also found that ?-endorphin works with the pancreas for the production of insulin.[4]

Improves depression: Research discovered that agmatine sulfate has a positive effect on those suffering from depression. Although the effects are not as strong as medication typically prescribed for the condition such as Tofranil; it does have the capacity to reduce anxiety and elevate mode. Agmatine also works well when used in combination with Wellbutrin which is an anti-depression drug.[5]

Reduces Cortisol, Anxiety and Stress: When the body is under stress, it releases a hormone called cortisol. Although the body naturally produces cortisol, long term overexposure can have negative consequences and increase the risk of health problems such as:

  • Weight gain
  • Sleep problems
  • Concentration and memory impairment
  • Heart disease
  • Digestive problems
  • Anxiety
  • Depression [6]

Agmatine helps to reduce the negative impact that stress has on the body. Since it assists in reducing anxiety, it helps the brain cope with stress which limits the production of the stress hormone cortisol.[7]

Stroke prevention and healing: Agmatine limits neuro damage to the brain caused during a stroke because it acts as a neuro protector. Studies have also found that it has the potential to protect the body against stroke by dilating the blood vessels in the brain to increase blood flow.[8]

Pain reduction: A study of 61 patients conducted discovered that after taking agmatine supplementation for 10 days, they experienced a reduction in pain from a herniated lumbar disk, it also enhanced their overall quality of life.[9]

Stimulate muscle growth: Studies have found that agmatine stimulates the production of the luteinizing hormone (LH) in rats. Testosterone levels are increased by high levels of LH. This creates the best hormonal environment for muscle growth and improved athletic performance.[10],[11]

Agmatine sulfate erectile dysfunction: Agmatine enhances sex drive and improves erectile dysfunction.[12]

Epilepsy and Seizures: Seizures are less likely to occur because agmatine increases the seizure threshold. When seizures do occur, agmatine shortens the length of them. Studies also suggest that agmatine enhances the effects of antiepileptic drugs such as valproate and phenobarbital.[13]

Protects the kidneys: Research has found that agmatine benefits the kidneys in several ways. Inflammatory and blood vessel diseases damage the kidneys, agmatine protects against this damage. It also improves the overall function of the kidneys by accelerating the blood filter rate of the kidneys. One of the main factors that determines kidney health is the rate at which it filters blood. This is how doctors determine whether the kidneys are healthy or not.[14]

Type 2 Diabetes: Type 2 diabetes cause the cells in the body to reject insulin. Drugs for the condition work by boosting the cells response to insulin. Drugs such as glipizide and glyburide work by stimulating the pancreas to produce more insulin. When diabetes is in its advanced stages, patients require insulin injections to treat the disease.[15]

Studies have found that agmatine stimulates the pancreas so that it produces insulin. It also has an insulin like effect on the cells. Therefore, studies suggest that agmatine might be a positive addition to type 2 diabetes treatment.[16]

Agmatine and Other Supplements

Technically, agmatine is a supplement; therefore, no official drug interactions have been recorded. However, since it does have an effect on many different parts of the body, caution is advised especially for people with underlying heart conditions. Agmatines action on nitric oxide is an indication that it contains ingredients that boost heart pressure, heart rate and vascularity. Therefore, it is advised that users do not combine agmatine with products that have similar effects; these include the following:

  • D-Aspartic Acid
  • Creatine
  • Rauwolscine
  • Yohimbine
  • L-Citrulline
  • L-Arginine [17]

Growth hormone boosters work well with agmatine, they provide a greater ergogenic enhancement.[18]

Frequently Asked Questions

Is Agmatine safe?

The body produces agmatine naturally; therefore, used within normal levels, it is not a dangerous product.[19]

Apart from minor side effects, there have been no reported casualties from ingesting agmatine. However, agmatine is intended for healthy adults over the age of 18. You should consult your doctor before using the product, especially if you are taking any over the counter or prescription medication. You should also consult your physician before taking agmatine if you suffer from, or have suffered from any of the following conditions:

  • Prostate enlargement
  • Diabetes
  • Psychiatric disease
  • Seizure disorder
  • Thyroid disease
  • Kidney disease
  • Liver disease
  • Heart disease
  • Stroke
  • Cardiac arrhythmia
  • High or low blood pressure [20]

Once you have started to take agmatine, and you begin to experience any adverse reactions, stop using it and consult a health care professional immediately.[21]

Pregnant or nursing women should not take agmatine; you should also stop using the product 2 weeks before an operation.[22]

It should not be used in combination with erectile dysfunction medication.[23]

Research has discovered that there were no negative side effects in rats after consuming high doses over a three-month period. The only effects noticed were slight reductions in blood pressure and body weight. Clinical trials have found that it is safe for humans to consume 3.5 grams per day for 21 days. Two researchers took 2.6 grams of agmatine daily for five years and did not experience any negative side effects.[24]

Side Effects

According to the patent for agmatine, trial participants were given low doses of agmatine, three reported gastrointestinal disruptions such as vomiting, nausea and diarrhoea. One participant dropped out of the trial due to the negative side effects.[25]

Agmatine increases appetite; however, this is beneficial for those who want to gain weight or bulk up.[26]

If you suffer from low blood pressure, agmatine can reduce it even further.[27]

Does agmatine cause cold sores?

When nitric oxide levels in the blood are too high the herpes simplex virus is activated which can cause cold sores. Therefore, it is advised that you stick within the recommended dosage to avoid agmatine sulphate herpes.[28]

Does agmatine work?

Yes, as discussed in the health benefits section, agmatine improves depression, blood insulin, protects against stroke, kidney damage, seizures and diabetes, it’s a pain reliever and it assists in the muscle building process.

What are gnc kratom capsules?

Kratom is a supplement that calms anxiety, relives pain and helps to reduce opioid withdrawal symptoms. Kramtom is a Southeast Asian tropical tree, the leaves have been used for centuries as a form of pain medication.[29]

How much agmatine to take?


There have been no studies conducted on dosage; however, manufacturers recommend taking between 750mg to 2.5g per day.[30]

What is agmapure?

Agmapure is the purest form of agmatine. When agmatine is taken through the process of hydrolysis it produces a chemical called putrescine. Agmapure does not contain this chemical.[31]

When to take agmatine sulfate

There is no recommended time of day for taking argmatine, it is up to the personal preference of the individual. However, to fully experience the nitric oxide boosting effects, the best time to take it is 15-30 minutes before exercise.[32]

How to take agmatine

Agmatine either comes in the form of a supplement or as agmatine sulfate powder. Both of which are taken by athletes to enhance performance. Agmatine should be taken on an empty stomach or either 30 to 60 minutes before or after consuming protein. How it is taken is important because agmatine uses the same transporters that are used to synthesize protein. Health experts recommend rotating your intake of agmatine to avoid building up a tolerance. It is advised that you take the product for three days and then take one day off.[33]

Where to buy agmatine

You can purchase agmatine sulfate from the majority of health food stores such as GNC.[34] It is also available from regular grocery stores such as Walmart,[35] and it can be purchased online through Amazon.[36]

Additional Information

It is essential that agmatine is not taken with alcohol, cocaine, beta blockers, Viagra or nitrates. Combining agmatine with recreational drugs and heart attenuation medication can cause cardiac arrest, a sudden drop in blood pressure and death. Nitrates, Clot Busters, Alpha Blockers and Beta blockers all have an effect on the heart; therefore, it is advised that you check with your healthcare practitioner before combining them.[37]



What does Agmatine taste like?

To some, Agmatine may have a slightly bitter taste. For those looking to sweeten their Agmatine, we suggest using our Monk Fruit Extract. Powder City also offers Agmatine capsules, or make your own using our encapsulation kit. Here are some of the Agmatine lot organoleptic test results:

Does Agmatine make a good pre-workout supplement?

Many users testify to Agmatine contributing to full pumps, improved focus and increased energy levels, without the stimulants you might find in other pre-workout products. However, there are products commonly found in pre-workout drinks, such as L-Citrulline, L-Arginine, Yohimbine, D-Aspartic Acid and Creatine, that should be avoided while consuming Agmatine, as they are shown to hinder its effectiveness.

What can you stack Agmatine with?

Try stacking Agmatine with supplement like Alpha-GPC, which is shown to increase growth hormone levels, in order to maximize on its ergogenic properties. Also, consider taking Agmatine with a carbohydrate source, as it can boost the process of glycogen re-synthesis.

Curated Reviews

“Very good stuff! I was surprised and very pleased with how potent this stuff is, even more how fast it kicks in. It’s like amped up L-arginine. If you tend to be a bit “high strung,” this stuff relaxes you and brings you back into focus quickly. Very relaxing. Great for a pump if you lift weights, like the N.O. supplements, but in a pure form. The “pumped up” effect also works on your male-parts during romantic bedroom activities☺ I will definately be ordering more of this in larger amounts! Powder City’s customer service is awesome! I got my order from PA all the way in Seattle in 2 days!”““ Bob M.

“Excellent. From the perspective of distance runner, I feel a noticeable effect on endurance when taken 30-45 minutes prior (on an empty stomach) and believe in its mild antinociceptive properties as well. I have tried citrulline malate, L-arginine, and AAKG, but agmatine is a winner in my book. I’m curious to see if it will act as a sleep/recovery aid at night as some have reported. Of note, powdercity’s customer service was helpful, thorough, and just. Thank you for the assistance. No doubts in quality.”““ Anonymous

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  17. John E. Piletz, Sounder Regunathan, Paul Ernsberger: Agmatine and Imidazoline. New York Academy of Sciences: 2003.
  18. John E. Piletz, Sounder Regunathan, Paul Ernsberger: Agmatine and Imidazoline. New York Academy of Sciences: 2003.
Also known as:(4-aminobutyl)guanidine
Good for: , , , , , , ,
Stacks well with: Creatine,Alpha GPC
Typical dose:750mg to 2.5g per day
Half Life :2 hours