7.0 /10


7.0 /10


8.0 /10


Boost Energy
Bulk Powder
Improve Focus
Improve Memory
Pre Workout



Centrophenoxine, also known as meclofenoxate, is a nootropic supplement that was initially marketed as a drug for the treatment of dementia, senile squalor syndrome, Alzheimer’s disease, and other age-related cognitive disorders. [1] It is sold worldwide under the brand name Lucidril.

Dietary supplementation with centrophenoxine has been shown to not only stall mental retardation, but even reverse some of the symptoms of cognitive decline. [2] [3] Furthermore, centrophenoxine is an effective nootropic for improved cognition, memory, and overall brain health. [4] As such, Lucidril is also used by healthy individuals as a preventative measure against brain damage.

Centrophenoxine is made up of two components: dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

DMAE is a naturally occurring substance found in seafood, and in particular, fish. Trace amounts can also be detected in the human brain. Labelled as a cholinergic nootropic, DMAE works by increasing acetylcholine levels in the brain. [5]

pCPA is a synthetic compound that was developed to replicate the role of a class of plant growth hormones called auxins. [6]

The several potential centrophenoxine benefits published in a variety of animal and human studies, include:

Delaying the Effects of Ageing

Long-term treatment with centrophenoxine reduced the accumulation of lipofuscin in human cells in vitro. [3] Lipofuscin is an age pigment that is indicative of cellular aging. [7] Less lipofuscin in the cells following intake of centrophenoxine supplement suggests that it is an effective aging disrupter. In elderly rats especially, the centrophenoxine effects were correlated with a decline in lipofuscin concentration in the brain. [4] [8]

Improving Memory and Recall

The prescription of centrophenoxine improved overall memory functions in elderly patients who suffer from medium level dementias. [9] Improvements also appeared to increase with age. Likewise, the effect of centrophenoxine enhanced memory consolidation, especially in older subjects. [10] Memory consolidation is the process in which the brain commits short-term recall into long-term memories. [11] These improvements to long-term memory are due to an increase in acetylcholine levels in the brain. [12]

Boosting Cognition and Brain Function

The cholinergic properties of centrophenoxine stimulated the brain’s acetylcholine supply in rats. [13] Increased amounts of acetylcholine in the brain has been shown to offset cognitive deficits within the neural network. [13] More efficient brain function was also observed in older mice compared with younger mice, after three months of centrophenoxine treatment. [4]

Enhancing Focus and Concentration

Centrophenoxine spurred metabolic activity in the brain cells of old rats. [14] [15] After six weeks of centrophenoxine treatment, the rats showed an increase in antioxidant enzyme activity in various regions of the brain. [15] These antioxidant enzymes play a role in our ability to maintain focus and concentration. Furthermore, healthy elderly subjects reported a significant increase in mental alertness after centrophenoxine treatment. [10]

Enabling Better Learning

Old mice treated with centrophenoxine required significantly less trial attempts than untreated mice to successfully navigate a maze task. [4] Similarly, centrophenoxine treatment enhances one’s ability to retrieve previously acquired knowledge to facilitate effective problem solving. [10]

Promoting More Positive Moods

The prolonged intake of centrophenoxine diminished symptoms of anxiety and depression in elderly patients with dementia. [15] In a rat study, the treatment of centrophenoxine suggested anti-anxiety effects. [16] The rats that were given a centrophenoxine dosage exhibited significantly less anxious behaviour than the untreated rats. [16]

Removing Waste and Toxins in the Brain

The effect of centrophenoxine has been shown to demonstrate neuroprotective benefits. Aging is partly attributed to damage caused by free radicals. [17] The accumulation of free radicals contributes to oxidative stress. [18] Centrophenoxine fights off oxidative stress by reducing the concentration of free radicals in the brain. [17] The administration of centrophenoxine also triggered an increase in antioxidative enzyme activity in several regions of the aging rat brain. [14] [15] [19]

How Centrophenoxine Works

The addition of pCPA to DMAE in the synthesis of centrophenoxine improves the nootropic’s ability to permeate the blood-brain barrier (BBB). [20] The BBB is the brain’s defence against harm, as it controls what can and cannot pass through. Within centrophenoxine, DMAE readily crosses the BBB and maintains an active effect on the brain. Centrophenoxine is a fat soluble compound, so it is easily broken down in the liver. [22] The better centrophenoxine diffuses across the BBB, the better its absorption directly into the cells of the brain. [21]

Centrophenoxine is a cholinergic nootropic because it stimulates the production of acetylcholine in the brain by preventing its uptake by other organs in the body. By increasing the concentration of acetylcholine in the brain, the cognitive nutrition effects of centrophenoxine are intensified. [23] In particular, the cerebral cortex and the hippocampus have shown elevated levels of acetylcholine. [4] Both the cerebral cortex and the hippocampus play a primary role in determining intelligence, memory formation, and learning behaviour. [24] [25] Acetylcholine has been associated with improved cognition, including memory, concentration, and learning. [5] [13] [15]

Centrophenoxine has also been reported to stimulate brain activity by accelerating glucose metabolism in the brain. [14] [26] Glucose is an essential metabolic fuel for the brain. [26] An increase in glucose uptake in the brain suggests that the brain has an ample supply of glucose. This enables the brain to absorb more glucose, and in turn, fulfill higher cognitive demands without fatiguing. [26]


Relative to other nootropics, centrophenoxine is one of the milder ones and is usually well-tolerated by most users. However, it is always safest to start taking centrophenoxine gradually, especially if this is your first time taking a dietary supplement. Generally, the daily centrophenoxine dosage for healthy individuals is 500mg to 1000mg. Most people tend to take centrophenoxine 250mg or 500mg twice a day, so the total daily dosage is split in half per dose.

If you intend on taking centrophenoxine for the treatment of age-related cognitive disorders, you should first consult with a healthcare provider for their recommendations.

Since centrophenoxine is fat soluble, it is best taken with food. For it to take full effect, centrophenoxine needs to travel through the digestive process before it can enter the bloodstream. The body experiences better absorption in the presence of food with higher fat content. At the very least, a smoothie with centrophenoxine supplement would work in a pinch. And given its energizing properties, it is probably best to avoid taking centrophenoxine before bed. As a result, the recommended times to take centrophenoxine are in the morning after breakfast and in the afternoon after lunch.

Centrophenoxine comes in two forms: centrophenoxine powder and centrophenoxine capsules. The choice is yours, but in general, capsules cost slightly more than powder. Centrophenoxine capsules are arguably more convenient as well. Just pack them to go and never forget to take your dose. However, if you are interested in nootropic stacking, centrophenoxine powder is more appropriate. Simply combine all of your desired nootropic supplements to create your very own neuroenhancer. The only thing to keep in mind is quality assurance and control. It is more difficult to examine the purity of the centrophenoxine in powder form than in capsule form. You can also buy centrophenoxine in the form of Lucidril tablets.

Side Effects

The centrophenoxine side effects are minimal. However, some users may experience mild side effects, including headache, nausea, joint or muscle weakness, gastrointestinal discomfort, restlessness, and trouble falling asleep. If any of these symptoms occur, take a break from centrophenoxine until the side effect subsides. It is also good practice to only take the centrophenoxine nootropic five or six days out of the week. Skipping a day or two gives your body a rest from supplementation.

Centrophenoxine does contain DMAE, which is known to cause birth defects in pregnant women. As a result, centrophenoxine should not be used by women of childbearing age.

Some users have reported mood disorders following supplementation with centrophenoxine. [27] If you suffer from anxiety or depression, it is best to steer clear of centrophenoxine entirely.


Centrophenoxine stacks well with several other smart drugs. These include the aniracetam centrophenoxine stack, the oxiracetam stack, the piracetam stack, and the noopept stack. All of the aforementioned smart drugs are considered racetams. Racetams are a group of nootropics that share similar chemical structures and thus, similar effects and benefits.

For anyone looking to create the ultimate neuroenhancer, stacking any combination of these smart drugs will offer defence against symptoms of cognitive decline, such as memory loss, toxic build-up in the brain, and mental retardation.

Although not absolutely necessary, pairing smart drug stacks with a choline supplement like Alpha-GPC has been shown to boost cognition further in some users. Choline is the precursor to acetylcholine, so it would make sense to take Alpha-GPC prior to taking the noopept centrophenoxine stack, for example.

It should also be noted that some users have reported fatigue or brain fog after using an aniracetam centrophenoxine stack. This could be due to the more depressive attribute of aniracetam. If you opt for aniracetam, it is probably best to skip Alpha-GPC.


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  1. https://www.ncbi.nlm.nih.gov/pubmed/16137852
  2. https://www.ncbi.nlm.nih.gov/pubmed/7558197
  3. https://www.ncbi.nlm.nih.gov/pubmed/6191765
  4. https://www.ncbi.nlm.nih.gov/pubmed/342588
  5. https://www.ncbi.nlm.nih.gov/pubmed/22300295
  6. https://www.ncbi.nlm.nih.gov/pubmed/27459816
  7. https://www.ncbi.nlm.nih.gov/pubmed/14764321
  8. https://www.ncbi.nlm.nih.gov/pubmed/8367013
  9. https://www.ncbi.nlm.nih.gov/pubmed/2506844
  10. https://www.ncbi.nlm.nih.gov/pubmed/329662
  11. https://www.sciencedirect.com/science/article/pii/S0896627315007618
  12. https://www.ncbi.nlm.nih.gov/pubmed/6806676
  13. https://www.ncbi.nlm.nih.gov/pubmed/15569402
  14. https://www.ncbi.nlm.nih.gov/pubmed/372050?dopt=Abstract
  15. https://www.ncbi.nlm.nih.gov/pubmed/8030848
  16. https://www.ncbi.nlm.nih.gov/pubmed/2896427
  17. https://www.ncbi.nlm.nih.gov/pubmed/16137852
  18. https://www.ncbi.nlm.nih.gov/pubmed/?term=PMC3614697
  19. https://www.ncbi.nlm.nih.gov/pubmed/6416880
  20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617654/
  21. https://www.ncbi.nlm.nih.gov/pubmed/15207256
  22. https://www.ncbi.nlm.nih.gov/pubmed/17688990
  23. https://www.ncbi.nlm.nih.gov/pubmed/120108
  24. https://www.ncbi.nlm.nih.gov/pubmed/3921995
  25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548359/
  26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497292/
  27. https://www.ncbi.nlm.nih.gov/pubmed/111283


Also known as:CAS Number: 3685-84-5
Good for: , , , , , , ,
Stacks well with: Coming soon…
Typical dose:250mg or 500mg twice a day
Half Life :Coming soon...