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Centrophenoxine is a nootropic supplement that was initially marketed as a drug for the treatment of dementia, senile squalor syndrome, Alzheimer’s disease, and other age-related cognitive disorders. [1]

Centrophenoxine is made up of: dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

Delaying the Effects of Ageing

Long-term treatment with centrophenoxine reduced the accumulation of lipofuscin in human cells in vitro. [2] Lipofuscin is an age pigment that is indicative of cellular aging. [3]

Improving Memory and Recall

Centrophenoxine improved overall memory function in elderly patients suffering from medium level dementias. [4]. Likewise, the effect of centrophenoxine enhanced memory consolidation, especially in older subjects. [5]

Boosting Cognition and Brain Function

The cholinergic properties of centrophenoxine stimulated the brain’s acetylcholine supply in rats. [6] More efficient brain function was also observed in older mice compared with younger mice, after three months of centrophenoxine treatment. [7]

Enhancing Focus and Concentration

Centrophenoxine spurred metabolic activity in the brain cells of old rats. [8] [9] After six weeks of centrophenoxine treatment, rats showed an increase in antioxidant enzyme activity in various regions of the brain. [9] Furthermore, healthy elderly subjects reported a significant increase in mental alertness after centrophenoxine treatment. [5]

Promoting Positive Moods

The prolonged intake of centrophenoxine diminished symptoms of anxiety and depression in elderly patients with dementia. [9]

Removing Waste and Toxins in the Brain

Centrophenoxine may have neuroprotective benefits. Centrophenoxine fights off oxidative stress by reducing the concentration of free radicals in the brain. [10] Administration of centrophenoxine also triggered an increase in antioxidative enzyme activity in several regions of the aging rat brain. [8] [9] [11]

How Centrophenoxine Works

Centrophenoxine is a cholinergic as it stimulates the production of acetylcholine in the brain by preventing its uptake by other organs in the body.[12] Acetylcholine has been associated with improved cognition, including memory, concentration, and learning. [13] [6] [9]

Centrophenoxine has also been reported to stimulate brain activity by accelerating glucose metabolism in the brain. [8] [15] Glucose is an essential metabolic fuel for the brain. [15]


Daily centrophenoxine dosage (for healthy individuals) is 500mg – 1000mg. Most people tend to take centrophenoxine 250mg or 500mg twice daily.

The recommended times to take centrophenoxine are in the morning after breakfast and in the afternoon after lunch.

Centrophenoxine comes in two forms: centrophenoxine powder and centrophenoxine capsules. Centrophenoxine capsules are arguably more convenient as well.

Side Effects

Users may experience mild side effects, including headache, nausea, joint or muscle weakness, gastrointestinal discomfort, restlessness, and trouble falling asleep.

Centrophenoxine contains DMAE, which is known to cause birth defects in pregnant women. Centrophenoxine should not be used by women of childbearing age.

Some users have reported mood disorders following supplementation with centrophenoxine. [14] If you suffer from anxiety or depression, it is best to steer clear of centrophenoxine entirely.


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  1. https://www.ncbi.nlm.nih.gov/pubmed/16137852
  2. https://www.ncbi.nlm.nih.gov/pubmed/6191765
  3. https://www.ncbi.nlm.nih.gov/pubmed/14764321
  4. https://www.ncbi.nlm.nih.gov/pubmed/2506844
  5. https://www.ncbi.nlm.nih.gov/pubmed/329662
  6. https://www.ncbi.nlm.nih.gov/pubmed/15569402
  7. https://www.ncbi.nlm.nih.gov/pubmed/342588
  8. https://www.ncbi.nlm.nih.gov/pubmed/372050?dopt=Abstract
  9. https://www.ncbi.nlm.nih.gov/pubmed/8030848
  10. https://www.ncbi.nlm.nih.gov/pubmed/16137852
  11. https://www.ncbi.nlm.nih.gov/pubmed/6416880
  12. https://www.ncbi.nlm.nih.gov/pubmed/120108
  13. https://www.ncbi.nlm.nih.gov/pubmed/22300295
  14. https://www.ncbi.nlm.nih.gov/pubmed/111283
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497292/
Also known as:CAS Number: 3685-84-5
Good for: , , , , , , ,
Stacks well with: Coming soon…
Typical dose:250mg or 500mg twice a day
Half Life :Coming soon...