5-HTP (5-Hydroxytryptophan)

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5-HTP is also available in capsules.

5-HTP (5-Hydroxytryptophan) Defined

5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and precursor to serotonin, a principle neurotransmitter involved in enhancing mood. It is also a metabolic intermediate in the biosysnthesis of melatonin from L-Tryptophan. [1] 5-HTP is found in the seeds of the Griffonia simplicifolia herb, a climbing shrub native to Central and West Africa. [2] 5-HTP has pronounced effects because it crosses the blood barrier with ease. [8]

5 HTP Benefits


While 5-HTP and L-Tryptophan are both precursors to serotonin, L-Tryptophan is sometimes converted into niacin — whereas 5-HTP is capable of converting only to serotonin — which makes it a good supplement choice for enhancing mood. A study found that when combined with Carbidopa, 200mg of 5-HTP improved mood in 43.4% of subjects. [3]

Body Composition

Appetite suppression is another benefit of 5-HTP supplementation and along with diet and exercise can help in maintaining a healthy body composition.

One study found a 38% reduction in calories compared to the placebo. [6] Another study found that 2 weeks of 5-HTP supplementation decreased the amount of carbohydrates consumed, with 75% of calories reduced coming from carbohydrate reduction [7] .

Additional Benefits

When combined with GABA, 5-HTP can reduce the amount of time needed to fall asleep. 5-HTP increases serotonin levels, which in turn increases melatonin levels since melatonin is a metabolic product of serotonin. Melatonin is responsible for regulating the sleep cycle, so by this mechanism 5-HTP promotes sleep. [9]

5 HTP Dosage

The recommended dosage is 100mg twice daily.

Synonyms: 5-hydroxytryptophan

Curated Reviews

After taking 100 to 200mgs of 5 htp. I sleep astoundingly better. I used to wake 3 to 5 times a night and have a hard time falling back to sleep. Now I wake up once, or twice a night but I fall back asleep quickly. I remember my dreams now too! I feel much much better now. – Tom G

This site is top notch. The product is great, I definitely feel a mood boost after taking it a few days in a row. I like to take it at night, since it does make you a bit sleepy. I will go a few days off of it and still be pretty good. Great stuff, great site. I will most definitely order from them again. – Viv


  1. https://www.ncbi.nlm.nih.gov/pubmed/22142813
  2. https://www.ncbi.nlm.nih.gov/pubmed/21178946
  3. http://www.ncbi.nlm.nih.gov/pubmed/6967194
  4. http://www.ncbi.nlm.nih.gov/pubmed/21178946
  5. http://www.ncbi.nlm.nih.gov/pubmed/12559480
  6. http://www.ncbi.nlm.nih.gov/pubmed/2468734
  7. http://www.ncbi.nlm.nih.gov/pubmed/9705024
  8. http://www.ncbi.nlm.nih.gov/pubmed/18445233
  9. http://www.ncbi.nlm.nih.gov/pubmed/19417589
  10. http://www.ncbi.nlm.nih.gov/pubmed/339807

Additional Resources

5-HTP Examine Page
5-HTP Wiki

Additional information

Weight0.101 kg


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