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Short for N-phenylacetyl-L-prolylglycine ethyl ester, Noopept is a nootropic supplement with psychostimulatory properties. Like piracetam, Noopept enhances natural cognitive abilities, but it is effective at much lower doses since it’s about 1000 times stronger. [1]. It also comes with neuroprotective benefits, which makes Noopept especially helpful for patients who have experienced brain injuries or other types of physical trauma.

“Noopept […] has now spawned an incredible improvement in myself. I am much more confident, far more verbally acrobatic, and I am able to socialize and interact with people on a whole other level than I have in quite some time, possibly better than ever.”

Noopept Benefits and Effects

Studies on humans and animals suggest many possible uses for Noopept including:

Enhancing Memory And Cognition

Rats who were given Noopept learned how to perform simple tasks quicker than their peers, and results seemed to improve with repeated dosing. Since learning and memory are closely tied, Noopept may help improve both traits in humans. [2]

Alleviating Anxiety

Noopept supplements also reduced anxiety in rats. Anxiety and memory are believed to be associated, so helping one should help the other. [3]

Regulating Emotion After Brain Injuries

Patients with vascular and traumatic brain injuries often suffer from short term emotional instability after the event. In a study, 53 such patients were given 10mg of Noopept twice daily for eight weeks while another group of similar patients were given 400mg of piracetam three times per day over the same time period. Noopept was more effective at reducing anxiety, irritability, headaches, sleep disturbances and daytime drowsiness. It also boosted patients’ mood and energy, It’s worth noting that some participants had adverse reactions that made their existing symptoms worse, but Noopept helped most patients improve. [4]

Lowering Stress

Noopept lowered stress induced protein activity in rats, so it could have potential for reducing symptoms of anxiety in humans. [5] Noopept also reduced symptoms of neurosis and learned helplessness in rodents. [6]

Treating Alzheimer’s And Parkinson’s Diseases

In test tube studies, Noopept has demonstrated neuroprotective properties, which means that it defends brain cells against damage from amyloid toxicity, oxidative damage and mitochondrial cell death. Consequently, Noopept might slow the progression of conditions like Alzheimer’s and Parkinson’s diseases. [7] [8]

Controlling Diabetes

Rats with type 1 diabetes given Noopept saw increased levels of incretin, which stimulates insulin secretion. Therefore, Noopept could potentially prevent symptoms of diabetes in humans. [9]

Reducing Inflammation and Increasing White Blood Cells

Noopept reduced inflammation in rats with bacterial infections while mice given Noopept experienced white blood cell growth and improved response to antigens. Therefore, Noopept may have immune system boosting benefits. [10] [11]

Aiding Thermoregulation

In a study of 127 healthy human volunteers, Noopept helped people adapt more quickly to both hot and cold environments. It also increased subjects’ capacity to work in warm conditions. [12]

Stopping Strokes

By preventing blood clotting and defending against lipid oxidation, Noopept may lower your risk of stroke. [13] [14]

How Noopept Works

What is Noopept Used For?

Noopept is believed to promote memory, focus and mental clarity by inhibiting the breakdown of glutamate, a neurotransmitter that is integral to cognitive functioning. Once ingested, Noopept crosses the blood-brain barrier almost instantaneously. According to Noopept reviews online, users report feeling the drug’s effects with 10-20 minutes.

Research on how Noopept works is currently limited to animal studies. In rats, Noopept stimulates the hippocampus and hypothalamus. [15] It also increases nerve growth factors, DNA transcription factors and Alpha and Beta brain waves. [16] [17]

What is Noopept Made From?

Noopept is a synthetically produced peptide. It is specifically designed to be fast-acting.

Noopept vs Piracetam

Noopept studies are ongoing, but research so far indicates that the nootropic has most of the same effects as piracetam including aiding memory formation and processing. However, in some areas, Noopept has outperformed piracetam. Additionally, it can help with memory consolidation and retrieval. As an antioxidant and an anti-inflammatory drug, Noopept could have other short and long term positive effects.

Noopept vs Aniracetam

Aniracetam is more powerful than piracetam, yet it’s not as potent as Noopept. While all three have similar effects, it’s not uncommon to combine them.

Noopept Dosage

Noopept is extremely potent, ao you don’t need very much to feel its effects. Because Noopept gets metabolized so quickly, Noopept’s half life is incredibly short. Therefore, taking several smaller doses throughout the day is more effective than taking a single large dose. Since it metabolizes on its own so quickly, there’s no need to take Noopept pre workout.


Pramiracetam VS Noopept


Strength1000x more potent than the original racetam10-15x more potent than the original racetam
EffectsBoosts mood, lowers aniety, and enhances cognitionBoosts cognition and productivity
Method of actionModulates AMPA receptors to increase synaptic plasticity leading to many cognitive benefits.Boosts the rate of acetylcholine synthesis to help the brain form new neurons and improve working memory.
Cost per dose$0.05-$0.16$0.83

Noopept is typically consumed as a powder, but you can also find Noopept capsules and even Noopept nasal spray. Noopept powder can be ingested by itself or mixed with water. The currently recommended Noopept powder dosage is 10-30mg per day. More research is needed to determine an optimal dose for humans. Nonetheless, there’s no reason to take more than 40mg in a 24-hour period.

When deciding how much Noopept to take, your goal should be to find the minimal effective dose. Start with 10mg per day and see how you feel before increasing your amount. Since it has stimulating effects, try to avoid taking Noopept before bed.

Due to its potency, most people cycle on and off of Noopept. Some packages recommend 1-3 weeks on followed by a month-long break. Others suggest taking Noopept for as long as eight weeks followed by a break of only four days. Reviews of Noopept on Reddit and other websites claim that Noopept has no effect on some individuals.

Noopept Side Effects

Like most nootropics, Noopept is safe for the majority of adults. The most notable adverse effect is increased blood pressure, which can cause other mild inconveniences like headaches, dizziness and fatigue. Therefore, people prone hypertension should carefully monitor their blood pressure when taking Noopept.

These side effects tend to be associated with taking higher doses. Consuming Noopept with caffeine may also increase anxiety. In studies comparing Noopept and Piracetam, Noopept appears to be better tolerated by most people. [18]

Noopept safety studies on rabbits seem to suggest that high levels of Noopept do not result in toxicity, so a Noopept overdose is unlikely. Noopept withdrawal symptoms are rare, but they can include mild anxiety, depression, irritability and brain fog. [19]

Noopept Stacks

Noopept is powerful enough on its own for most people, but many users have found that stacking Noopept with other nootropics can enhance its cognitive benefits. Below are some examples of common Noopept stacks:

Noopept, Piracetam, and Choline
(10mg of Noopept, 2g of piracetam and 300mg of Alpha GPC once or twice daily)

Although Noopept and piracetam are similar, they affect two different neurotransmitters, so taking both may produce a synergistic effect. Adding choline to the mix further boosts piracetam’s abilities while also preventing headaches. Noopept and Alpha GPC stack especially well together.

Noopept, Aniracetam and Sulbutiamine
(10mg of Noopept, 1g of aniracetam and 300mg of Alpha GPC once or twice daily)

This trio can boost your mood, creativity and mental clarity. Just remember that you must cycle sulbutiamine to avoid developing a tolerance.

Other Noopept Stacks

If you want a brain and muscle boost, try taking Noopept with choline. Noopept and oxiracetam also stack well together. Another popular noopept stack is Noopept and Modafinil, which is good for concentration.

Mixing nootropic drugs is fairly safe so long as you adhere to recommended dosages, so feel free to experiment within those ranges. Different ratios may work better for different individuals. There are also preformulated nootropic blends, such as the Mind Lab Pro Stack, that pair well with Noopept.




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