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What is Sarcosine?

Sarcosine is a byproduct of glycine that can boost mood and improve memory. It is chemically similar to glycine as well as D-serine, but is much more bioavailable than the latter. Sarcosine works by blocking GlyT1, a transporter that increases glycine and D-serine uptake into cells. This means there is more of both of these amino acids in the body to enhance their nootropic benefits.

Sarcosine Side Effects and Benefits

In both rodent and human studies, sarcosine has shown to provide cognitive benefits in healthy and young participants. This effect is supplementary to its main glycine and D-serine boosting activities [1, 2, 3]. Similar to D-serine, sarcosine can also improve social memory performance and motor skills [4, 5].

While more research is needed, preliminary evidence indicates sarcosine can elevate mood. This is unsurprising, as D-serine has also been noted as a mood boosting agent [6, 7]. When combined with D-Aspartic Acid, sarcosine has a synergizing effect that can further enhance its mood boosting effects as well as provide a boost in testosterone.

While sarcosine itself does not pose many risks, there has been a noted correlation between naturally high levels of sarcosine and damaged prostate cells. This has nothing to do with supplementation and is not caused by taking sarcosine; it is merely a useful biomarker [8].Â

Sarcosine Dosage

Individuals should take 1.5-3g of sarcosine per day. When first starting a nootropic regimen, be sure to take the smallest effective dose to determine how the supplement affects you. Sarcosine is water soluble, so it is best taken on an empty stomach. Unlike many nootropics which are frequently bitter, sarcosine is sweet in taste.

CAS Number: 107-97-1
Synonyms: N-methylglycine



Additional Resources

Sarcosine Wikipedia Entry

Sarcosine Examine Entry


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