Rutaecarpine (from Evodia Rutaecarpa)

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What is Rutaecarpine (Evodia Rutaecarpa)?

Rutaecarpine is a compound isolated from the berries produced by Tetradium ruticarpum (also sometimes referred to as Evodia rutaecarpa) which is a tree found in China and Korea. It has a long history of usage in traditional Chinese remedies.

This compound has one very unusual function: it counteracts caffeine. [1,2]

Rutaecarpine: The Anti-Caffeine Substance

Caffeine is a necessity for many individuals. It comes in many shapes and forms, being present in coffee, tea, energy drinks, pre-workout mixes, capsules, and so on. While there is nothing wrong with caffeine for most of us – it does what it is supposed to do and it does it very well – it can be a problem when you want to get some sleep or relaxation after a long day. By supplementing with Rutaecarpine, your body will be much better at eliminating caffeine. This means you can consume caffeine later in the day without disrupting your sleep. For example, when supplementing with Rutaecarpine you can use a pre-workout that contains caffeine during late-afternoon workouts or drink coffee later in the day if you need an energy boost. Caffeine has a half-life that can last up to 7 hours [3] which can inhibit your ability to rest. Rutaecarpine helps to reduce this, by increasing the breakdown of caffeine within the body. It also comes in handy for those taking caffeine pills as it makes the duration much more controllable, reducing the need for strict dosing schedules.

Other Evodia Rutaecarpa Benefits

The main function of Rutaecarpine is reducing the unwanted effects of caffeine, but that’s not all Rutaecarpine has to offer. It also acts as a novelty anti-inflammatory. [4] It does this by inhibiting COX-2 (cyclooxygenase-2), the enzyme responsible for inflammation. [4]

Rutaecarpine can induce vasorelaxation [5] along with a positive effect on nitric oxide formation. [6]

The above benefits make Rutaecarpine an even better choice for including in a pre-workout mix. Dose caffeine first, then after the caffeine starts working take a dose of Rutaecarpine so that the caffeine is eliminated after your workout – all while reaping the additional benefits.

Rutaecarpine Side Effects

Rutaecarpine increases the workings of the CYP1A2, CYP2B, and CYP2E1 enzymes. [7,8] This is also the mechanism that allows Rutaecarpine to eliminate caffeine so rapidly. If you take other substances that are metabolized by these enzymes Rutaecarpine will heavily decrease their half-lives.

If you are not sure if any compound you are taking is metabolized by one of these enzymes, please consult a health care professional.

No other serious side effects are known.

Evodia Rutaecarpa Dosage

Take up to 100mg twice a day on an as-needed basis for caffeine elimination or other health benefits.

To get an extra anti-caffeine boost Rutaecarpine can be stacked with L-Theanine. L-Theanine is also great on its own, especially when combined with caffeine.

CAS Number: 84-26-4
Synonyms: Rutecarpine, Rutacarpine, Rhetine



Additional Resources

Rutecarpine Wikipedia Entry

Additional information

Weight0.105 g

1 Gram Tub, 5 Grams, 10 Grams


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