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Sunifiram (DM-235)

Synonyms: DM-235, N-Methylpyrolidone, Piperazine

At the core, most nootropic users are after one thing: a brain that operates more efficiently and effectively. Whether it's learning faster, retaining more information, or simply being primed for optimal basic functioning, if there's a good way to improve what's already working, it's open for discussion.

This search for the top nootropics to improve cognition has brought many new products to light, including sunifiram. Though sunifiram is relatively young compared to most nootropics, available studies and anecdotal user comments are exciting and drawing comparisons to long time nootropic heavy hitter piracetam, but with almost 1,000 times higher potency.

Sunifiram's ability to improve memory and improve overall cognition have made it one of the top nootropics available today.

What is Sunifiram?

Sunifiram, also referred to as DM-235 in scientific reports, is a piracetam derivative, which may explain the common association with the racetam class. However, sunifiram isn't part of the racetam class due to certain portions of the structure changing in the derivative process.

Like racetams, sunifiram works by enhancing AMPA receptors in the brain, which are related to the brain's synaptic transmissions and found throughout the nervous system.  Since these receptors are so common and the function is so essential, maximizing operation of the AMPA receptors via nootropics is a one way ticket to cognitive enhancement [1].  Sunifiram also stimulates release of acetylcholine, a chemical created by the brain that is critical to memory function [2].

How Sunifiram Benefits You

When you look at the benefits of sunifiram, you start to see why it draws comparisons to the most popular nootropics available. From students to the elderly, it has something to offer for everyone.

  • Improved memory in otherwise healthy brains, making sunifiram a must-use for college students and working professionals. [4]
  • Cognitive enhancement in situations with a cognitive deficit including brain damage or other age-related brain deterioration. [3][5]
  • Enhanced acetylcholine secretion. [5]
  • Low toxicity at higher doses. Like piracetam, sunifiram seems to be relatively safe to take at higher doses. [4, 6]

Sunifiram Dosage

As mentioned above, sunifiram has potency much higher than the average racetam-like nootropic. This results in much lower doses required to achieve the desired effect. Recommended doses are around 0.08-0.16mg/kg of bodyweight. However, the recommended range above is rather wide when extrapolated out, with one end being double the other, so as with all nootropics, a lower dosage is recommended at first with small increases until it reaches maximum effectiveness. For a 150lb person, this would translate to 5.4-11mg. 



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Sunifiram (DM-235) Reviews
4.7 out of 5, based on 3 reviews
Ray from Burnaby BC on Dec 17, 2014
Interesting noot. 1 scoop did almost nothing. Next day 2 scoops was perfect. A bit stimulating, like a cup of strong green tea but without jitters. This lasted about 3-4 hours, after which I crashed mildly. I found that hearing was enhanced, BUT even base parts sounded tinny, which was very unpleasant. I will save this one for times I need a quick 4 hour burst of energy, and don't mind the crash and the sound.
Andrew from Michigan on Nov 21, 2014
With Sunifiram, I have had multiple amazing results, however, somewhat contradictory to what others have experienced. Let me explain:

I looked though my package late at night and I mistook Sunifiram for a different package so I took a micro-scoop. My eyesight immediately improved. Everything was sharper and clearer. I went to bed an hour later than usual due to the extra energy and then woke up 2 hours earlier with an unusually high amount of energy, good mood, and desire to work. For the next 3 days, my brain focus, drive, memory, and creativity were literally off the charts. I was creating engineering solutions in mere hours what had taken several days previously. I was remembering how to do things from college that I had long forgotten. For the next couple nights my sleep was better than it had been for a number of years. The effects wore off after almost exactly 3 days. For the next week I functioned slightly higher than normal (due to some products that PowderCity offers).

A couple weeks later, after reviewing other’s experiences about Sunifiram, I returned to my shipping box and remembered that I had taken it by accident at night and wondered if that was what happened. I tried it again, and I had the same results... better eyesight, creativity, less but better sleep, working at a much higher capacity for three days off a single microscoop! And let me add, no crash, just a soft return. I have repeated this 4x... each with the same result. And BTW, I have had no noticeable tolerance to the substance as of yet.

I am definitely ordering this from PowderCity again. They have the absolute best prices and quick delivery (to USA).

One final note, everyone’s chemistry is different. This product is simply amazing to my chemistry. FYI, I follow a low carb, moderate protein, Ketogenic diet, with spirits. I also take a number of other supplements from PowderCity. This may have improved my results.
John Mitchell from Australia on Nov 17, 2014
Really cool noot. Very similar in potency to Modafinil :)


This nootropic is not considered a dietary supplement and as such should only be taken under the guidance of a doctor or in a research setting.

Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Always consult a physician if you are unsure about taking a new supplement or nootropic. Do not take this product if you are under 18, if you are pregnant, nursing, or have any cardiovascular issues.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.