Hordenine HCL

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Part of the reason that fat loss can be so difficult is that there are so many dimensions to why we eat and why we eat too much. Metabolic levels are important if we want to burn fat, but sometimes it just isn't enough and we need to eat less food as well.

Now, people are starting to use a simple compound found in certain grasses that could increase metabolism and decrease appetite. It might just be the supplement you've been looking for to help you reach your body fat goals.

Popular among those training for strength and fat loss, Hordenine has a broad appeal among the health conscious.

What is Hordenine HCL?

Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a natural phenethylamine compound that occurs in different plants, notably barley grass.[1] It is structurally related to the amino acid tyramine.[1] Methylation of tyramine creates N-methyltyramine and Hordenine.[1]

This supplement works primarily through the release and protection of norepinephrine, much like other weight-loss supplements.[2] This would explain the benefits of increased metabolism and energy, as well as the decrease in appetite which is apparently a result of slowed digestion.

Users supplement Hordenine for three main effects: fat loss, appetite control, and energy. It is used in many bodybuilding pre-workout stacks for its synergistic effects with PEA.

Hordenine Effects

Researchers have indicated that Hordenine, as part of a more complete supplemental regimen, can produce increased energy expenditure in healthy people.[2] This leads to more calories being burned, even while you're not working out.

Hordenine can also lead to an increase in the release of norepinephrine and a reduction in the metabolic destruction of norepinephrine.[2] This effect on the adrenergic system could explain its purported results and the success some people find through Hordenine supplementation.

Known as a very powerful key to weight reduction, norepinephrine helps increase metabolism and significantly reduce appetite.[3] By activating norepinephrine, Hordenine might work much like other very effective weight-loss compounds.[3]

Hordenine is often used in conjunction with other exercise and weight-loss improving supplements to reach the desired outcome of more energy and less fat.

Hordenine Dosage

Users typically take Hordenine multiple times a day to maintain its effect. A dose of about 25 mg three times a day is a good start. Some people find Hordenine dosages works best with the addition of PEA, caffeine anhydrous, or yohimbine.


  1. Proceedings of the Biochemical Society [pdf]
  2. Thermogenic effect of an acute ingestion of a weight loss supplement
  3. Predictors of weight loss and maintenance in patients treated with antiobesity drugs

Additional Resources


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*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.

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