Methylene Blue

6.7

Memory

6.0 /10

Antioxidant

8.0 /10

Longevity

6.0 /10

Methylene Blue

Boost Energy
Cognitive
Depression Support
Immune Support
Improve Memory
Mental Health
Nootropics
Mood Support

Description

Summary

Methylene blue is a synthetic compound [1] [2], and its role is primarily neuroprotective. The drug is well known for improvements in memory, mood, and brain health. [6] [7] [8] [9] [10]

Benefits and Effects

Preventing Low Blood Pressure

Septic shock is the severe drop in blood pressure that occurs when a damaged organ becomes infected. [1] Methylene blue stain has been found to be effective against septic shock by elevating mean arterial pressure. [1] [18]

Improving Short-Term Memory and Cognitive Function

Methylene blue may improve short-term memory in both healthy and Alzheimer’s disease mice models. [11] [12] [13] In humans, oral administration of low methylene blue dosage enhances to short-term memory tasks, sustains attention, and memory retrieval. [13] [14]

Methylene blue was taken by healthy adults before and after completing tasks [13] Methylene blue increased brain activity in the regions responsible for visuospatial short-term memory tasks [14] [15]

Alleviating Symptoms of Depression and Anxiety

Methylene blue has anti- anxiety and depression properties. [8] [9] [10] Across two studies, subjects with bipolar/manic-depressive disorder were prescribed methylene blue treatment for 6 and 24 months. [8] [10] Participants receiving up to 300 mg/day showed significant anti-depressive effect than low doses of methylene blue (15 mg/day). [8] [10]

However, in a separate three-week trial, 15 mg/day treatment proved to be effective in severely depressive patients. [9]

 Protecting the Brain

Mitochondrial dysfunction has been associated early neuropathological symptoms. [5] [6] [16] Problems in energy production in brain mitochondria can lead to an overproduction of reactive oxygen species (ROS) [5] [16] [17].

In rats with Parkinson’s disease, the administration of methylene blue successfully reduced the production of ROS and other harmful free radicals. [5]

The antioxidant effect of methylene blue slows the rate of aging without effecting ATP production. [5] [17]

How Methylene Blue Works

Methylene blue acts as an antioxidant [4] [5] [16] and its activity may restore normal mitochondrial function and cellular metabolism in the brain. [5] [19]

Electron ‘leakage’ can occur, impacting cellular energy, and causing ROS production. [5] [16] [17]

ROS can cause damage to cellular components and lead to premature aging. [5] [17]

Methylene blue treatment may attenuate overproduction of ROS, delaying mitochondrial dysfunction. [20]

Dosage

A safe starting dosage is 0.5 mg/kg of body weight, and is not toxic at low doses. However, 2 mg/kg is the upper limit dosage for rescue treatment, when the patient’s blood pressure is low. [1]

Rescue dosages, taken on a daily basis, is not recommended due to the risk of high blood pressure. [21]

Side Effects

Methylene blue side effects are mild and temporary. [1] Most common side effect of methylene blue is urine colour; changing urine colour to a shade of greenish blue.

Methylene blue may also cause skin discolouration. Toxicity can occur at high doses.

Symptoms could include arrhythmia, coronary vasoconstriction, and decreased blood circulation throughout the body. [1] Only ingest pharmaceutical grade.

 

Sources

Sources

  1. https://www.ncbi.nlm.nih.gov/pubmed/21547182
  2. https://jamanetwork.com/journals/jama/article-abstract/241035
  3. https://www.ncbi.nlm.nih.gov/pubmed/23443659
  4. https://www.sciencedirect.com/science/article/abs/pii/S0006295209003359
  5. https://www.ncbi.nlm.nih.gov/pubmed/21454572/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265679/
  7. https://www.ncbi.nlm.nih.gov/pubmed/25018057
  8. https://www.ncbi.nlm.nih.gov/pubmed/3091097/
  9. https://www.ncbi.nlm.nih.gov/pubmed/3555627/
  10. https://www.ncbi.nlm.nih.gov/pubmed/27284082
  11. https://www.ncbi.nlm.nih.gov/pubmed/20731659
  12. https://www.ncbi.nlm.nih.gov/pubmed/14724055/
  13. https://www.ncbi.nlm.nih.gov/pubmed/15792783
  14. https://pubs.rsna.org/doi/10.1148/radiol.2016152893
  15. https://www.ncbi.nlm.nih.gov/pubmed/26961091
  16. https://www.ncbi.nlm.nih.gov/pubmed/28840449
  17. https://www.ncbi.nlm.nih.gov/pubmed/27247702
  18. https://www.ncbi.nlm.nih.gov/pubmed/17095500/
  19. https://www.sciencedirect.com/science/article/abs/pii/S0006295213007417
  20. https://www.ncbi.nlm.nih.gov/pubmed/17928358
  21. https://www.ncbi.nlm.nih.gov/pubmed/17258030
  22. https://www.ncbi.nlm.nih.gov/pubmed/15976222/
Also known as:Methylene Blue, Urolene Blue, Provayblue, Proveblue
Type:Nootropic
Good for: , , , , , , ,
Stacks well with: Adrafinil
Typical dose:2 mg per kg of body weight.
Half Life :5hr
Methylene Blue

Methylene Blue

Boost Energy
Cognitive
Depression Support
Immune Support
Improve Memory
Mental Health
Nootropics
Mood Support