Table of Contents
Methylene blue is a synthetic compound  , and its role is primarily neuroprotective. The drug is well known for improvements in memory, mood, and brain health.     
Benefits and Effects
Preventing Low Blood Pressure
Septic shock is the severe drop in blood pressure that occurs when a damaged organ becomes infected.  Methylene blue stain has been found to be effective against septic shock by elevating mean arterial pressure.  
Improving Short-Term Memory and Cognitive Function
Methylene blue may improve short-term memory in both healthy and Alzheimer’s disease mice models.    In humans, oral administration of low methylene blue dosage enhances to short-term memory tasks, sustains attention, and memory retrieval.  
Methylene blue was taken by healthy adults before and after completing tasks  Methylene blue increased brain activity in the regions responsible for visuospatial short-term memory tasks  
Alleviating Symptoms of Depression and Anxiety
Methylene blue has anti- anxiety and depression properties.    Across two studies, subjects with bipolar/manic-depressive disorder were prescribed methylene blue treatment for 6 and 24 months.   Participants receiving up to 300 mg/day showed significant anti-depressive effect than low doses of methylene blue (15 mg/day).  
However, in a separate three-week trial, 15 mg/day treatment proved to be effective in severely depressive patients. 
Protecting the Brain
Mitochondrial dysfunction has been associated early neuropathological symptoms.    Problems in energy production in brain mitochondria can lead to an overproduction of reactive oxygen species (ROS)   .
In rats with Parkinson’s disease, the administration of methylene blue successfully reduced the production of ROS and other harmful free radicals. 
The antioxidant effect of methylene blue slows the rate of aging without effecting ATP production.  
How Methylene Blue Works
Methylene blue acts as an antioxidant    and its activity may restore normal mitochondrial function and cellular metabolism in the brain.  
Electron ‘leakage’ can occur, impacting cellular energy, and causing ROS production.   
ROS can cause damage to cellular components and lead to premature aging.  
Methylene blue treatment may attenuate overproduction of ROS, delaying mitochondrial dysfunction. 
A safe starting dosage is 0.5 mg/kg of body weight, and is not toxic at low doses. However, 2 mg/kg is the upper limit dosage for rescue treatment, when the patient’s blood pressure is low. 
Rescue dosages, taken on a daily basis, is not recommended due to the risk of high blood pressure. 
Methylene blue side effects are mild and temporary.  Most common side effect of methylene blue is urine colour; changing urine colour to a shade of greenish blue.
Methylene blue may also cause skin discolouration. Toxicity can occur at high doses.
Symptoms could include arrhythmia, coronary vasoconstriction, and decreased blood circulation throughout the body.  Only ingest pharmaceutical grade.