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What is L-Lysine?

L-Lysine, more simply known as Lysine, is an essential amino acid that must be obtained through diet or supplementation. Some common dietary sources include fish, meats, cheeses, and soy; however, direct supplementation guarantees you are getting an accurate dose to reap maximum benefits.

Lysine is a building block for protein and is essential for promoting a number of functions including muscle growth, carnitine production, calcium absorption and more. Because of this, this amino acid is a popular preworkout supplement and is a frequent addition to preworkout stacks. Lysine also has potential as an anxiolytic, helping to promote relaxation.

Lysine Benefits

Promotes Lean Muscle Mass

This is also a popular preworkout supplement due to its synergy with Arginine When paired together, these two supplements enhance growth hormone production [4]. Lysine is also vital for building and maintaining muscle as low levels of this amino acid are linked with slower protein synthesis, which is how your body repairs and builds muscle following a workout [5, 6, 7]. When combined with vitamin C, lysine converts into carnitine, which your body then uses to metabolize fat [7].

Additional Uses

Lysine also has positive implications for bone and joint health. This affect is amplified by the addition of arginine, as this synergistic pairing that supplements bone health [9].

L-Lysine Dosage

Individuals should take 500mg one to two times per day. The recommended dosage by body weight is 12 mg/kg, which correlates to roughly 815mg for a 150lb adult. Start with the lowest effective lysine dosage to establish a baseline before increasing.

CAS Number:?_56-87-1

Synonyms:?_2,6-Diaminohexanoic acid; 2,6-Diammoniohexanoic acid


  1. http://www.ncbi.nlm.nih.gov/pubmed/6790230
  2. Embleton, Phil J., and Gerard Thorne. Musclemag International’s Anabolic Primer: An Information-packed Reference Guide to Ergogenic Aids for Hardcore Bodybuilders. Mississauga, Ont.: Musclemag International, 1998.
  3. http://www.ncbi.nlm.nih.gov/pubmed/9013429
  4. http://umm.edu/health/medical/altmed/supplement/lysine
  5. http://www.ncbi.nlm.nih.gov/pubmed/11393808

Additional Resources

L-Lysine Wikipedia Entry

Additional information

Weight0.532 g

500 Grams


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