What is Alpha-Hydroxy-Isocaproic Acid (HICA)?
Alpha-hydroxy-isocaproic acid, also known as DL-alpha-hydroxy-isocaproic acid, leucic acid, DL-2-hydroxy-4-methvylaeric acid and HICA, results from leucine metabolism in human tissues and is highly valued by athletes. It belongs to the branched chain amino acid leucine, which plays a significant role in supplementing the synthesis of muscle protein.
HICA is also produced during fermentation, and therefore scan be found in certain foods including wines and cheeses. 
Benefits of HICA
HICA consumption has positive benefits for athletes and bodybuilders interested promoting recovery after intense workouts. Studies reveal that athletes who consume alpha-hydroxy-isocaproic acid experienced an increase in lean mass in their lower extremities.* 
Another study showed the increase in lean mass also has a direct relationship on weight increase resulting from an increase in lean mass.* 
Daily Dosage of HICA
Human studies focused on consuming of 1,500 mg daily, split into three divided doses of 500 mg.
- Walser M. Composition for promotion of protein synthesis and suppression of urea formation in the body utilizing alpha-hydroxy-acid analogs of amoni acids. US Patent 1 444 621. 1973.
- Applied Microbiology and Biotechnology April 2004, Volume 64, Issue 3, pp 396-402