Description
Chemical Information
Table of Contents
Images
Known Chemical Data
| Systematic (IUPAC) name | (RS)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanone |
| Chemical Name | α-Pyrrolidinopropiophenone |
| Identifiers | |
| CAS Number | 19134-50-0 |
| ATC code | |
| PubChem | 209045 |
| ChemSpider | 181124 |
| Chemical data | |
| Formula | C13H17NO |
| Molar mass | 203.28 g/mol |
| Online Synonyms | |
| 1. alpha-Pyrrolidinopropiophenone 2. 1-phenyl-2-pyrrolidin-1-ylpropan-1-one 3. 19134-50-0 4. 1-Phenyl-2-(1-pyrrolidinyl)-1-propanone 5. 1-Propanone, 1-phenyl-2-(1-pyrrolidinyl)- 6. alpha-PPP 7. a-Pyrrolidinopropiophenone 8. AC1L4LUY 9. alpha-Pyrrolizinopropiophenone 10. SCHEMBL11037118 11. CTK4E0631 12. KPUJAQRFIJAORQ-UHFFFAOYSA-N 13. Propiophenone, 2-(1-pyrrolidinyl)- 14. AKOS009049710 15. HE043929 16. HE321759 17. 1-phenyl-2-(pyrrolidin-1-yl)propan-1-one 18. 1-Propanone,1-phenyl-2-(1-pyrrolidinyl)- 19. KB-160328 20. LS-123161
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Discovery, History & Research
Discovery
Alpha-PPP was first described in a US based patent filed by Behrendt; Wilhelm A. (Niederweimar, Kreis Marburg, DT), Stieh; Bernhard (Marburg, DT) back in March 1975. This patent with application number 05/554,902 was finally granted and published in 1977.
History
Since its first official discussion in the above patent, Alpha-PP has been primarily as a stimulant and appetite suppressant drug similar to its chemical cousin diethylpropion. Unlike many of the other research chemicals available on the market today, Alpha-PPP has been well researched, with even some in vivo animal studies having been conducted over the year.
In Germany it was detected in some “ecstasy” labelled tablets seized by German law enforcement. After some time in the research chemical landscape, it was made illegal in the UK’s blanket ban as a substituted cathinone and may even be considered for scheduling the USA within the analogue act.
Research
Although there have been some interesting in vivo studies, in general, resesearh is limited. However, below is a list of some of the more notable publications:
Chemical Structural Data
As a structural analogue of Diethylcathinone, Alpha-PPP is technically a Cathinone, sharing many of the same chamical attributes. Alpha-PPP is also a related drug to ’-methyl-α-pyrrolidinopropiophenone (MPPP).
Structure-Activity & Chemical Similarity Predictions
Based on the available chemical structural data and information already understood from its chemical analogues and cousins, Alpha-PPP is thought to act on the Norepinephrine and Dopamine pathway, with potential for action withing the Seretonin transporter protein. Further information, based on its few in vivo studies on male Winstar rats shows its ability to be metabolized into many metabolites, including Cathinone itself.
Key Areas of Research
Samples of Alpha-PPP to purchase online may be used in the following scientific applications.
- As a forensic sample and/or for forensic chemical catalogues.
- As a reference sample for Toxicology laboratories.
- As a chemical reagent and/or intermediate
- Pharmaceutical Intermediate
- As a research chemical sample within studying pharmacology of receptor binding assays. Particularly receptors involved Cathinone binding drugs.
- Affinity and Efficacy Receptor profiling.
- Reference sample for the application within future therapeutic compounds
- Pure reference standard for chemical analytical libraries using HPLC, FTIR, NMR and GC/MS equipment
Online Anecdotal Reports
Alpha-PPP has found its way into various online anecdotal discussion boards with the majority of people willing to talk about Alpha-PPP experiences and reviews on platforms such as Errowid and Reddit after reading about it on the Alpha-PPP Wikipedia page.
Below is a collection of some of the larger Alpha-PPP forum posts.
Forum links to anecdotal discussion by those who are able to buy Alpha- PPP online.
Chemical Safety, Legality & Indented Use
Intended use
This is a research chemical compound. Sold as an analytical standard, reagent or laboratory tool for in vitro (outside a living organism) research only. This compound is not for human consumption or any form or in vivo research.
Legality
It is the sole responsibility of the purchaser to ensure this compound is legal to purchase and import for research chemical purposes in their country.
Chemical Safety
This compound is intended to be used in strict laboratory conditions, following all proper precautionary protocol for any novel and untested chemical. The toxicological and physiological action of this compound have not been assessed and so extreme caution should be observed when handling this compound. Please follow proper health and safety guidelines, in a well ventilated and well equipped laboratory when handling this compound.
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