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Chemical Information



5F-MDMB-PINACA structure


Known Chemical Data

Systematic (IUPAC) nameMethyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
Chemical Name5f-mdmb-pinaca
CAS Number1715016-75-3
ATC code 
PubChem 101895417


Chemical data 
Molar mass377.46 g·mol−1
Online Synonyms
  1. 5F-Mdmb-pinaca
  2. 5-Fluoro-ADB
  3. 5F-Adb
  4. 5-Fluoro-adb, (+/-)-
  5. 5F-Adb, (+/-)-
  6. Methyl (S)-2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate
  7. Valine, N-((1-(5-fluoropentyl)-1H-indazol-3-yl)carbonyl)-3-methyl-, methyl ester
  8. 1715016-75-3
  9. 5-fluoro MDMB-PINACA






Discovery, History & Research


Although there does not seem to be an official discovery date linked to 5F-MDMB-PINACA directly, it may have been first discussed in this study published in 2015. However, it may be likely that the “discovery” of 5F-MDMB-PINACA was more loosely related to a more general group cannabinoid patent which may have covered 5F-MDMB-PINACA as part of the patent description.


Since if first few mentions in 2015 it has had a number of studies conducted. One of which was on its pharmacology with information regarding its biding affinity at the cannabinoid receptors. Other research has been showing it flagged as a potential for formal scheduling in several countries due to its dangers as being sold online.


There is one piece of research published in Analytical ad Bioanalytical Chemistry, describing the Ki values of 5F-MDMB-PINACA at the CB1 cannabinoid receptor in 2015. However, since then, the main publications have been toxicology reports and scheduling by various countries.


For some of the research found, see below:







Chemical Structural Data

5F-MDMB-PINACA is technically a structural analogue of AKB48 or APINACA. As a variation of ADB-PINACA, 5F-MDBM-PINACA is a a fluorinated version with at the terminal carbon atom of the pentyl group. The terminal amide amide group has been substituted with a methyl ester in 5F-MDBM-PINACA which makes it different from its chemical cousin; fluorinated ADB-PINACA.

Structure-Activity & Chemical Similarity Predictions

Based on the similarity that 5F-MDMB-PINACA holds with it chemical cousin AKB48, it would be fair to suggest a potent binding affinity for the cannabinoid receptor subgroup. With further potential binding (but unconfirmed) to the other cannabinoid receptors.

Research has shows that 5F-MDMB-PINACA has an affinity for the CB1 receptor as a potent agonist.

Key Areas of Research


Samples of 5F-MDMB-PINACA to purchase online may be used in the following scientific applications.  


  • As a forensic sample and/or for forensic chemical catalogues.
  • As a reference sample for Toxicology laboratories.
  • As a chemical reagent and/or intermediate
  • Pharmaceutical Intermediate
  • As a research chemical sample within studying pharmacology of receptor binding assays of common cannabinoid receptor subgroups, such as the CB1 receptor.
  • Affinity and Efficacy Receptor profiling.
  • Reference sample for the application within future therapeutic compounds
  • Pure reference standard for chemical analytical libraries using HPLC, FTIR, NMR and GC/MS equipment


Online Anecdotal Reports

Most online discussion regarding 5F-MDB-PINACA is either trying to identify the difference between the names, such as “what is the difference between 5F-MDBM-PINACA and 5F-ADB”

Further online discussion will openly and anecdotally talk about 5F-MDMB-PINACA experience and reviews, with further vendor discussion on where to buy 5F-MDMB-PINACA in the USA and UK.

There seems to be much more online discussion of 5F-MDMB-PINACA’s chemical analogues online, so specific discussion is on this chemical alone is limited.

Forum links to anecdotal discussion by those who are able to buy 5F-MDMB-PINACA crystals online.








Chemical Safety, Legality & Indented Use

Intended use

This is a research chemical compound. Sold as an analytical standard, reagent or laboratory tool for in vitro (outside a living organism) research only. This compound is not for human consumption or any form or in vivo research.


It is the sole responsibility of the purchaser to ensure this compound is legal to purchase and import for research chemical purposes in their country.

Chemical Safety

This compound is intended to be used in strict laboratory conditions, following all proper precautionary protocol for any novel and untested chemical. The toxicological and physiological action of this compound have not been assessed and so extreme caution should be observed when handling this compound. Please follow proper health and safety guidelines, in a well ventilated and well equipped laboratory when handling this compound.


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