SAM-e Supplement (S-Adenosyl Methionine)

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What is SAM-e?

SAMe is formed when the essential amino acid methionine and adenosine triphosphate (ATP) react within the body. SAMe works as a methyl donor, transferring a methyl group to another compound. This process is known as methylation, which is crucial to happiness and mental health.

SAM-e Benefits

The most common use for SAM-e is as a mood regulator; however, this supplement has many additional benefits relating to joint health, cardiovascular health, and cognition.

SAM-e Levels and Mood

Those suffering from mood imbalances may be experiencing low levels of SAM-e, so using a SAM-e supplement is crucial for boosting mood. SAM-e improves mood by increasing the turnover of serotonin and dopamine which are neurotransmitters responsible for happiness, energy, focus, and many other functions within the brain. [1,2]

SSRIs (Selective Serotonin Reuptake Inhibitors) are commonly prescribed to patients experiencing certain mood disturbances. Though some of these treatments are effective, they come with many negative side effects. Common side effects experienced during SSRI treatment include headaches, nausea, nervousness, drowsiness, and weight fluctuation. [3] SAM-e is better tolerated than most SSRIs and is proven to be just as effective in some individuals. [4,5,6]

SAM-e for Memory

SAM-e can improve memory decline especially in those experiencing deficits caused by mood imbalances. This supplement also improves social fluidity in those experiencing the same mood-related symptoms. [7] More studies are needed to find SAM-e’s efficacy as a memory enhancer in otherwise healthy individuals.

Cardiovascular Health

SAM-e may be able to assist in the health and protection of the cardiovascular system. This supplement can function as a vasodilator which allows blood to flow more efficiently throughout the vessels. [8] Vasodilators make it so the heart does not have to work as hard to pump blood throughout the body. S-adenosylmethionine also promotes smooth muscle cell function; however, the reason behind this has not yet been established. [9]

Joint Health

Other benefits of SAM-e are its role as an anti-inflammatory agent and its ability to improve joint comfort. This supplement also improves joint mobility. [10] SAM-e is shown to be just as effective as some of the over the counter anti-inflammatory products on the market. This supplement also seems to be better tolerated than other medications. [10,11,12]

SAM-e Side Effects

SAM-e supplements are commonly well tolerated by most individuals. Reported side effects include upset stomach, dizziness, and nervousness.

SAM-e Dosage

The recommended dosage of SAM-e is 800mg up to twice daily. Taking SAM-e with vitamins B6 and B12 may improve absorption and enhance the benefits SAM-e supplements. [13]



Review guidelines


*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.

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