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New to Nootropics?

Do you prefer tubs? 25g Pramiracetam Tub

Do you prefer capsules? Pramiracetam Capsules

Ever since the development or Piracetam in the 1970's, the racetam family of compounds has been a compelling route for people trying to improve general cognition, memory, and learning capabilities.

In the world of nootropics, the racetams are the go-to nootropics for boosting brain power. While there is some variety of racetam forms, and not all racetams are as well understood as the parent compound, one of the more widely known and studied is Pramiracetam.

What is it?


Pramiracetam is fat-soluble and will therefore NOT mix well with water. It is best to take fat-soluble racetams after a meal or with a fat source such as fish oil. Your body will not absorb or benefit from a fat-soluble racetam on an empty stomach.

Pramiracetam (N-[2-(dipropan-2-ylamino)ethyl]-2- (2-oxopyrrolidin-1-yl)acetamide) is a GABA-like compound and close relative of Piracetam.[1] The chemical difference between Pramiracetam and Piracetam is that where Piracetam has an amide, Pramiracetam has a dipropan-2-ylaminoethyl group.[1]

Pramiracetam is remarkable for high oral-bioavailability and high potency.[1] For this reason, users take Pramiracetam in smaller doses than Piracetam.[1]

This more potent racetam is sometimes taken as an alternative to Piracetam for people who don't feel Piracetam gives them the sense of well-being that they are after or people who don't want to take as much powder as Piracetam can require.

Side Effects and Benefits

As with other racetams, the direct mechanism of Pramiracetam is not fully known. It has been conjectured that racetams increase acetylcholine receptors, or are antioxidants, but more study is required. There is also speculation that racetams interact heavily with glutamate receptors, but, again, the action is unclear.[1]

Pramiracetam most likely works by increasing cholinergic neuronal impulse flow in specific regions of the brain based on certain in vitro observations.[1]

While the mechanisms are not clearly understood, the outcomes of the racetams have been looked into extensively.[1] Since Piracetam's first debut in the early 1970's, a lot of interest has been put into the many racetams.

Advantageous Pramiracetam side effects include improved memory and reduced delayed verbal recall.[1] There is also some evidence to suggest that Pramiracetam is superior to Piracetam in helping with memory retrieval and orientation.[1]

Pramiracetam has also shown to improve some test scores on cognitive ability up to three hours after being taken.[1] It remains a highly popular nootropic and an inexpensive way to optimize mental performance.


Users typically take Pramiracetam powder in doses around 250 mg a few times a day with meals. As with most racetams, many people take a choline source along with it. Some say taking choline along with the proper Pramiracetam dosage can improve the overall experience.


  1. Malykh, AG, and MR Sadaie. "Piracetam And Piracetam-Like Drugs: From Basic Science To Novel Clinical Applications To CNS Disorders." Drugs 70.3 (2010): 287-312. CINAHL with Full Text. Web. 3 Sept. 2012.

Additional Resources

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This nootropic is not considered a dietary supplement and as such should only be taken under the guidance of a doctor or in a research setting.

Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Always consult a physician if you are unsure about taking a new supplement or nootropic. Do not take this product if you are under 18, if you are pregnant, nursing, or have any cardiovascular issues.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.