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Phosphatidic acid (PA) is formed from phospholipids present in many foods. This supplement is popular with bodybuilders due to its ability to promote lean mass and exercise recovery.* Mediator® PA is generally recognized as a safe dietary supplement by the FDA. [1,2]
Mediator® Phosphatidic Acid Benefits
Phosphatidic acid is responsible for muscle recovery following intense exercise.* This is due to its ability to activate mammalian target of rapamycin (mTOR). [3,4] The mTOR pathway is responsible for the regulation of cell growth, cell motility, cell survival, and protein synthesis. Intense weightlifting, though crucial for lean mass, can cause muscle cell breakdown especially if overtraining.* Phosphatidic acid, when added to these types of exercises, prevents this cellular breakdown while increasing lean mass potential.*
By binding to P70S6K – another important component responsible for cell growth and protection –Phosphatidic acid stimulates anabolism for longer periods of time.  Without supplementation, the body only remains in an anabolic state for a short period of time following exercise.* The longer the body remains in the anabolic window, the longer the body produces muscle cells while utilizing fat cells for energy. 
Phosphatidic Acid: Proven Results
One study looked at 28 trained males with similar height and weight who participated in an 8-week resistance training program.  Half of these men were given Mediator® PA the other half were given a placebo. This 8-week program consisted of both hypertrophic and strength workouts. The results of this study showed the group given PA experienced positive results in body composition and lean mass. 
Another study consisting of 16 trained men competing in one repetition maximum squats showed a massive increase in strength gains.  Subjects that used a PA supplement gained 12.7% squat strength and a 2.6% increase in lean body mass compared to the control group’s 9.3% strength increase and 0.1% increase in lean body mass. 
Phosphatidic Acid Dosage
An oral daily dose of Mediator® PA is 1,500mg, which contains 750mg PA active.
Mediator® PA is a registered trademark of Chemi Nutra
Mediator® PA patents applied for with the U.S. Patent and Trademark Office by Chemi Nutra
- http://www.fda.gov/ohrms/dockets/dockets/05p0305/05p-0305-cr00001-04-Council-For-Responsible-Nutrition-vol1.pdf (Listed on Page 24)
- Joy, J., et al. The Effects of 8 Weeks of Phosphatidic Acid Supplementation on Cardiovascular, Kidney, and Liver Safety in Healthy Young Males
- Joy, J., et al. Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy
- Joy, J., et al. Phosphatidic Acid Supplementation Increases Skeletal Muscle Hypertrophy and Strength
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*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.
Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.
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