HICA (Leucic Acid)

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What is Alpha-Hydroxy-Isocaproic Acid (HICA)?

Alpha-hydroxy-isocaproic acid, also known as DL-alpha-hydroxy-isocaproic acid, leucic acid, DL-2-hydroxy-4-methvylaeric acid and HICA, results from leucine metabolism in human tissues and is highly valued by athletes. It belongs to the branched chain amino acid leucine, which plays a significant role in supplementing the synthesis of muscle protein.

HICA is also produced during fermentation, and therefore scan be found in certain foods including wines and cheeses. [1]

Benefits of HICA

HICA consumption has positive benefits for athletes and bodybuilders interested promoting recovery after intense workouts. Studies reveal that athletes who consume alpha-hydroxy-isocaproic acid experienced an increase in lean mass in their lower extremities.* [2]

Another study showed the increase in lean mass also has a direct relationship on weight increase resulting from an increase in lean mass.* [3]

Daily Dosage of HICA

Human studies focused on consuming of 1,500 mg daily, split into three divided doses of 500 mg.


  1. Walser M. Composition for promotion of protein synthesis and suppression of urea formation in the body utilizing alpha-hydroxy-acid analogs of amoni acids. US Patent 1 444 621. 1973.
  2. Applied Microbiology and Biotechnology April 2004, Volume 64, Issue 3, pp 396-402
  3. http://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-1

Additional Resources

Leucic Acid Examine Page
Leucic Acid Wiki

Review guidelines


*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.

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