L-Citrulline Malate 2:1

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L-Citrulline Malate benefits your performance at the gym by supplementing amino acid utilization in skeletal muscle and promoting healthy blood flow, while supporting ATP production [1]. After absorption, citrulline either maintains its structure or gets converted to arginine, an amino acid commonly consumed to supplement strength and endurance. Additionally, arginine may benefit mental clarity, alertness, & memory due to it being an intermediate in brain protein synthesis* [6].

What is Citrulline?

Citrulline is a non-protein amino acid, meaning it is not used to form proteins, which also means that it is not found in abundance in common food sources. Watermelon has the highest natural content of citrulline, despite watermelon having ~1g protein per serving. L-Citrulline is bonded to malic acid in a 2:1 ratio to result in citrulline malate.

L-Citrulline Benefits

Power & Strength

Citrulline malate enhances the ease at which one can obtain the "pump" due to it being a precursor to arginine. Promoting blood flow aids in recovery from exercise  This same mechanism is what allows it to promote creatine production and amino acid utilization in muscular tissue [3]. Physical strength benefits are common when taking citrulline malate, as one study showed a 23% increase in force output [1]. In another study done on trained weightlifters, citrulline malate increased reps per set, delayed fatigue, and decreased muscle soreness [2]. In addition to it benefits for strength, allowing you to perform more reps, and combating soreness, Citrulline Malate supplements the rate of phosphocreatine restoration post-workout [3]. This not only translates to strength benefits at the beginning of your workout, but maintaining high levels of strength throughout your workout, allowing you to tear through weights.*


Lactic acid is responsible for the burning sensation that occurs while exercising, and can also prevent you from running as far as you would like and lifting as long as you want to. The secondary action of citrulline malate is its ability to act as a buffer. It achieves this by supplementing the reabsorption of the body's natural buffers, such as bicarbonates* [5].

Literature points to a benefit to oxidative ATP production during exercise by up to 34%, which is likely due to malic acid being an intermediate in ATP production [3]. Put more simply, the malic acid component of this powder compliments the replenishment of ATP (energy) stores.*


Healthy blood flow is what allows L-citrulline malate to not only increase your performance at the gym, but also aid recovery outside of the gym as well* [4].

L-Citrulline vs Citrulline Malate Supplements

Citrulline malate is the form studied in patients with fatigue that has been shown to promote ATP production and creatine phosphate regeneration. L-citrulline alone has not been shown to have these benefits.

L-Citrulline Malate Dosage

The recommended dose is 3-6 grams per serving for optimal health and performance benefits. If you do not notice effects at this dosage, then increase up to 10 grams per day.

Start with a lower dosage and increase after assessing tolerance. If you find higher doses intolerable, experiment with split dosing before and after workouts, or at different times of the day.

For best results, take citrulline malate on an empty stomach in the morning or before bed. For performance benefits, consume within 15-60 minutes before a workout.

Synonyms: L-Citrulline DL-Malate, Stimol, Citrulline Malate


What is composition of your L-citrulline malate 2:1 powder?

Our L-Citrulline DL-Malate powder is 2 parts L-citrulline bonded with 1-part Malic Acid. In a serving size of 3g, 2g would be L-citrulline and 1g would be Malic acid by weight.

How should I take L-Citrulline Malate?

L-Citrulline Malate is best taken on an empty stomach early in the morning, at least half an hour before exercise, or prior to sleep.

Taking citrulline prior to sleep allows the body to continue delivering nutrients to the muscles to maintain an anabolic state.

Curated Reviews

"I had recently purchased a bit of supplements from here (now my second order through PC) I had bought about 10 different things. The shipping was crazy fast, I had purchased it 7/31 and everything had arrived in perfect shape to Ohio 8/3 could not be happier with the quality of the products I bought. I have been making a stack with of hordenine, horny goat weed, citrulline malate, creatine, beta alanine, and beta ecdysterone all from powder city and my lifts have never been better. Had a buddy try my stack in case it was just placebo, but he said he will be placing an order for the same stuff, he loved it as well. Sorry powder city I have been meaning to write a review but work has been delaying it, excellent service as always!"– Eric C.

"I've done my fair share of research on citrulline and felt that for my goals it was a must in my supplement cycle! I've purchased the 500g package twice. This is not only a great supplement in itself, but the quality that Powder City offers is promising! I took the product so often that I thought it lost its effect, but once I was forced to stop taking it (because I ran out) I noticed a difference immediately. Citrulline isn't only great for increasing your pumps and helping you lift more, but by increasing your nitric oxide you can reduce muscle soreness by up to 40%. The muscle soreness is what I noticed immediately! I love that this comes with a scoop and the measurement per serving is 3g. It makes it very easy to get the amount that I preferred (6g). I would highly recommend adding 6g to your pre-workout!"– Brian W.

"Eating right and taking all the extra nutrients in the world won't help, IF you can't deliver them where they are needed. I added this to my pre-exercise regimen along with a cup of coffee and niacin to open up the circulatory system and have noticed greater endurance and larger pumps and consistent week-over-week strength gains. I will reorder. NOTE - bitttterrrrr!!!!!!!! I couldn't take and was going to junk it UNTIL I started mixing 2 scoops in my Pomegranate Juice Concentrate and water. Don't notice the taste at all anymore. Good product."– Thomas M.


  1. http://www.ncbi.nlm.nih.gov/pubmed/21664351
  2. http://www.ncbi.nlm.nih.gov/pubmed/20386132
  3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1724533/pdf/v036p00282.pdf
  4. http://www.ncbi.nlm.nih.gov/pubmed/17953788
  5. http://www.ncbi.nlm.nih.gov/pubmed/1930358
  6. http://www.unboundmedicine.com/medline/citation/12701820

Additional Resources

Citrulline Malate Examine Page
Citrulline Malate Wiki

Review guidelines


*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.

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