Alpha-Lipoic Acid

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Alpha-Lipoic Acid is also available in capsules

What Is Alpha-Lipoic Acid?

Alpha Lipoic Acid (ALA) is a naturally occurring fatty acid. Common food sources of ALA include spinach, kidney, liver, tomatoes, and broccoli [1]. Supplementation is still advisable however because the levels of ALA found in food are generally not high enough to bestow benefits comparable to supplementation. ALA is unique compared to many other cellular health supplements because it is both fat soluble and water soluble, so it is easily absorbed and transported to organs and systems throughout the body [4].

Alpha Lipoic Acid Benefits

Antioxidative Properties

ALA can increase general antioxidative effects throughout the body. One study found that the level of glutathione in blood was significantly higher after supplementing with ALA [2]. Glutathione is an important cellular health supplement that protects against free radicals, peroxides, and heavy metals. ALA can also improve the functioning of endotheliums by decreasing oxygen-derived free radicals [3]. Endotheliums are an important part in many aspects of vascular biology, such as the transportation of white blood cells into and out of the bloodstream, blood clotting, and inflammation. Additionally, ALA can decrease lipid peroxidation [5]. When free radicals take electrons from the lipids in cell membranes and thus cause damage, that is called lipid peroxidation. This combination of antioxidative effects helps to promote longevity [9].

Muscle Building

One study found that when pairing creatine with alpha-lipoic acid, creatine concentrations in muscles were higher [6]. Creatine has been a staple supplement within the bodybuilding community for years because of its ability to increase growth hormone and improve strength gains, muscle energy, and body mass [7,8]

Appetite Control

This supplement can mimic a caloric surplus and suppress appetite. This effect is thought to be achieved by inhibiting 5' AMP-activated protein kinase (AMPK) in the hypothalamus [10]. AMPK is like a metabolic master switch that can sense energy levels by detecting changes in the AMP-to-ATP ratio that take place during exercise and rest. When this ability to detect changes in energy levels is weakened, less food is consumed. One study found that body composition was improved when supplementing with ALA [11].

Alpha Lipoic Acid Side Effects

Reported side effects include rash and tingling sensation.

Alpha Lipoic Acid Dosage

The recommended dosage is 300mg once or twice daily.

CAS Number: 1077-28-7
Synonyms: (RS)-5-(1,2-dithiolan-3-yl)pentanoic acid; α-Lipoic acid; Thioctic acid; 6,8-Dithiooctanoic acid

ALA and ALCAR Stack

Combining ALA and ALCAR provides stronger cellular health benefits. This combination is great for preworkout and longevity purposes.*

Take this stack in a 2:1 ratio for best results. The most common dosage is 500mg of ALCAR and 250mg of ALA.

Sources

  1. http://www.ncbi.nlm.nih.gov/pubmed/9570844
  2. http://www.ncbi.nlm.nih.gov/pubmed/18315507
  3. http://www.ncbi.nlm.nih.gov/pubmed/20162509
  4. http://www.ncbi.nlm.nih.gov/pubmed/18069903
  5. http://www.ncbi.nlm.nih.gov/pubmed/19231043
  6. http://www.ncbi.nlm.nih.gov/pubmed/14669930
  7. http://www.ncbi.nlm.nih.gov/pubmed/11297004
  8. http://www.ncbi.nlm.nih.gov/pubmed/16331129
  9. http://www.ncbi.nlm.nih.gov/pubmed/18789599
  10. http://www.ncbi.nlm.nih.gov/pubmed/15195087
  11. http://www.ncbi.nlm.nih.gov/pubmed/18344723

Additional Resources

Alpha-Lipoic Acid Wikipedia Entry

Alpha-Lipoic Acid Examine Entry

Review guidelines

Disclaimer

*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.

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