Alpha-GPC Powder 50%

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Alpha-GPC 50% Capsules are also available.

Alpha-GPC is a phospholipid metabolite and precursor to phosphatidylcholine and acetylcholine. [1] Alpha-GPC is considered one of the best choline supplements available as it only requires 46% of the dose of CDP-choline to achieve similar effects. [2] It is found in foods such as beef liver, oat bran, Atlantic cod, and milk — though not at levels high enough to be useful — so additional supplementation is worthwhile. [3]

Alpha-GPC Benefits

Cognitive Health

Alpha-GPC supplements general cognition. [4] Supplementing with Alpha-GPC promotes the translocation and activation of protein kinase C (PKC), which is responsible for short and long-term memory.* [7]

Alpha-GPC also supplements learning, thinking, and memorization. [5] Again, the translocation and activation of protein kinase C play a role in these benefits. [7] Phosphatidylserine, when taken with Alpha-GPC, can be synergistic in aiding the supplementation of cognition.* [6]


Alpha-GPC supplementation can also be beneficial for mood, memory, social behavior, and more. [2,8]  Alpha-GPC may also influence the release of GABA, a neurotransmitter that promotes calmness.* [2]

Physical Fitness

Alpha-GPC also benefits body composition and power output during exercise.* [9,10]

Alpha GPC Supplements and Stacking

Alpha-GPC enhances the effects of pre-workout products, bringing its benefits of focus and power to your workouts to make them as effective as possible.*

Alpha-GPC Dosage

For cognitive benefits, take 300mg-600mg (one flat 1.25cc scoop) per day blended with water, sports drink, or encapsulated. On workout days, try ingesting 600mg Alpha-GPC 45-60 minutes before training, to maximize its performance benefiting capabilities.

Synonyms: A-GPC, L-Alpha glycerylphosphorylcholin, Alpha glycerylphosphorylcholine, Choline Alphoscerate, glycerophosphocholine


Why just 50%?

Alpha-gpc is a hygroscopic supplement, meaning it absorbs water with ease. When water is absorbed the supplement can clump or turn into a paste making supplementing difficult. You will also see some companies using dicalcium phosphate with their alpha-gpc for these purposes. Silicon dioxide has a much better absorption rate which allows for the product to have a greater shelf life.

Silicon dioxide is not water soluble so only the alpha-gpc will dissolve when mixing in a beverage.

What if this supplement doesn’t work for me?

Everyone reacts differently to different choline sources. We carry many cholinergics including cdp choline, choline bitartrate, centrophenoxine, and phosphatidylserine.

Curated Reviews

"I'm new to nootropics and Powder City, and I'm still learning the right combinations for me. First of all, Powder City has been a great company to order merchandise from my initial order, through the tracking of merchandise sent to my e-mail to keep tabs on it, and ultimately receiving my purchase in excellent condition, on time, and the product itself worthy of my review/time here. Alpha-GPC 50 has worked well for me. I noticed better concentration and a heightened ability to recall information on demand within an hour or two after consumption. In my profession I have to have the utmost concentration and information/memory available instantaneously with absolute accuracy. So when I experience "it" as I have, then I know this is a good product. Of course I've combined Alpha-GPC with other nootropics, but this is the one I keep using consistently with different variations, so it's a star for me. I highly recommend Powder City for the quality of their product(s), prices, and service. Thank you and I have shared your company information with others."- Rabbit



Additional Resources

Alpha GPC Examine Page
Alpha GPC Wiki


Review guidelines


*Statements found within have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Consult with your physician before taking if you are pregnant, nursing, have any cardiovascular or other medical issues, or anticipate surgery. Keep out of the reach of children.

Scientific studies cited are not conclusive and have limitations, due to of their closed environment nature. Referenced studies will not necessarily determine your experience with a supplement or nootropic, since there are many unaccounted variables, which fall outside the scope of the studies.

The reviews contained within are the opinions of contributors and are not necessarily the views or opinions of Powder City. These reviews should not be taken as fact or recommendation, and are only opinions of products that the contributors may have or may have not used. Powder City makes no warranty, implied or expressed, to the accuracy of information provided by these reviews.

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